Medical Science
Volume 25, Issue 118, December 2021
Double test positive predictive value assessment for fetal defect screening in the first trimester of pregnancy at suburban district hospitals of Ho Chi Minh City
Tuan Vo1, Binh Pham1, Hoang Vu2♦, Nhat Ho3, Bao Vo4
1University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam
2University of Medicine Pham Ngoc Thach, Ho Chi Minh City, Vietnam
3Tu Du Hospital of Ho Chi Minh city, Vietnam
4University of Missouri – Kansas City, USA
♦Corresponding author
University of Medicine Pham Ngoc Thach, Ho Chi Minh City,
Vietnam
ABSTRACT
Objectives: To determine positive predictive value of Double test for fetal defect screening during the first trimester of pregnancy among high-risk cases by Double test at suburban hospitals of Ho Chi Minh City. Methods: Retrospective cohort study conducted in the period of December 2019 – April 2020. By total population sampling, study objects were 149 pregnant women who had gestational ages of 11-13+6 weeks, participated into prenatal screening with Double test in the first three months of pregnancy, and obtained a high-risk test result for at least one of the three trisomy disorders 21, 18 and 13 at 7 suburban hospitals of Ho Chi Minh City. Results: During 5 months of study conduction, 149 pregnant women had Double test results as high risk, it is recorded that predictive value of Double test in fetal defect screening during the first trimester of pregnancy was 5.3%. All high-risk Double test cases had a chromosomal anomaly of trisomy 21 via amniocentesis. Conclusion: Although positive predictive value is very low (5.3%) and false positive rate is high (94.7%), Double test still plays a role in antenatal screening in the first three months of pregnancy. However, when positive, counseling for pregnant women is needed to assure them that there are about 5 true deformities per every 100 high-risk cases. It is necessary to conduct more specialized tests for confirmed diagnosis.
Keywords: Free β-hCG, PAPP-A, NT, prenatal diagnosis, high risk
Medical Science, 2021, 25(118), 3078-3084
