Volume 25, Issue 117, November 2021

Effect of flaxseed oil on acetaminophen-induced hepatotoxicity in male rats

Reham A Arafat^1,2♦, Ghaidaa M Baghdadi¹

¹Department of Food and Nutrition, Faculty of Home Economics, King Abdulaziz University, Jaddah, Saudi Arabia
²Department of Nutrition and Food Science, Faculty of Home Economics, Helwan University, Egypt

^♦Corresponding author
Department of Food and Nutrition, Faculty of Home Economics, King Abdulaziz University, Jaddah, Saudi Arabia

ABSTRACT

The goal of this study was to explore if flaxseed oil (FSO) could protect male rats from hepatotoxicity caused by acetaminophen (APAP). Feed intake (FI), feed efficiency ratio (EFR) and body weight gain % (BWG %), as well as serum levels of liver enzymes (alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase, (ALP)) used to investigate these impacts. A liver histopathological investigation was also carried out. Methods: Fifty male Wister rats were divided into five groups at random: Group 1 is the negative group (Cont -), while Group 2 is the positive group (Cont +). The other three groups; rats were received oral gavages of FSO (1.5, 3 and 4.5ml/Kg/day) for 30 days and received the single dose of APAP (3 g/kg) at day 30 1 h before FSO respectively. Results: The results demonstrated that pretreatment with FSO (1.5, 3, and 4.5 ml/kg b.wt.) for 30 days improved FI, EFR, BWG percent, and lowered high serum levels of liver enzymes in hepatotoxic rats compared to the Cont+ group. The histopathological alterations generated by APAP were reduced in liver sections of rats given flaxseed oil. Conclusion: The results suggest that FSO induces potent hepatoprotective in acetaminophen hepatotoxic rats. Flaxseed oil consumption may be useful for people who have liver disorders, according to this study.

Keywords: Flaxseed oil, Liver enzymes, Oxidative stress, acetaminophen

Medical Science, 2021, 25(117), 2910-2916

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