Volume 25, Issue 116, October 2021

Assessment of effectiveness of platelet rich fibrin in comparison to open flap debridement in the treatment of three walled intrabony defects in stage II and stage III periodontitis: A clinical study

Gowri Pendyala^1♦, Subramaniam Rao², Preeti Byakod³, Swaroop Kumar Magar⁴, Asawari Lawande⁵, Saurabh Joshi⁶, Ameet Mani⁷

¹Reader, Department of Periodontics, Rural Dental College, Pravara Institute of Medical Sciences, Loni, Ahmednagar, Maharashtra, India
²Professor, Department of Periodontics, PMNM Dental College and Hospital, Bagalkot, Karnataka, India
³Professor, Department of Prosthodontics, Maratha Mandal Nathajirao G Halgekar dental college and research centre, Belgavi, Karnataka, India
⁴Professor, Department of Prosthodontics, Saraswati dhanwantri dental college, Perbhani, Maharashtra, India
⁵Senior Lecturer, Department of Periodontics, Late shri Yashwantrao Chavan Dental College, Ahmednagar, Maharashtra, India
⁶Reader, Department of Pedodontics, Rural Dental College, Pravara Institute of Medical Sciences, Loni, Ahmednagar, Maharashtra, India
⁷Professor, Department of Periodontics, Rural Dental College, Pravara Institute of Medical Sciences, Loni, Ahmednagar, Maharashtra, India

^♦Corresponding author
Reader, Department of Periodontics, Rural Dental College, Pravara Institute of Medical Sciences, Loni, Ahmednagar, Maharashtra, India

ABSTRACT

Background: Platelet Rich Fibrin, (PRF) a new generation Platelet concentrate, provisioned with simplified preparation and agglomeration of various growth factors has been used for regeneration of periodontal intrabony defects. The goal of this study was to evaluate and compare the effectiveness of Platelet Rich Fibrin with Open Flap Debridement (OFD) in the treatment of three walled bony defects in stage II and stage III Periodontitis. Method: In a split-mouth study design, fifty interproximal intrabony defects in 25 healthy patients diagnosed with Stage II and Stage III Periodontitis were randomly assigned to Open Flap Debridement group (Group I) or Platelet Rich Fibrin group along with Open Flap Debridement (Group II). Clinical pocket depth (PD), clinical attachment level (CAL) and radiographic (bone fill) measurements were made at baseline and at a 9 -month evaluation. Results: At 9 months postoperatively, upon comparing the PD reduction, defect depth reduction, and clinical attachment level gains, it was noted that group II showed statistically-significant improvements compared with group I in PD (3.62 ± 0.52 vs 5.30 ± 0.86 mm) CAL Gain (4.30 ± 0.87 vs 3.12 ± 0.29 mm), bone fill (5.12 ± 0.54 vs 8.96 ± 0.99mm). Conclusion: The results of this study indicate that PRF in comparison to OFD improve clinical and Radiographic Parameters associated with treatment of 3 walled intrabony Periodontal Defects.

Keywords: Regeneration, Intrabony defects, Platelet Rich Fibrin, Open Flap Debridement

Medical Science, 2021, 25(116), 2643-2651

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