Volume 25, Issue 111, May, 2021

Plexiform neurofibroma: An Arduous entity

Ayushi Singh^1♦, Anil Agrawal², Sunita Vagha³

¹Junior resident, Department of Pathology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Sawangi, Wardha, Maharashtra, India
²Professor, Department of Pathology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Sawangi, Wardha, Maharashtra, India
³Head of Department, Department of Pathology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Sawangi, Wardha, Maharashtra, India

^♦Corresponding author
Junior resident, Department of Pathology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Sawangi, Wardha, Maharashtra, India

ABSTRACT

Plexiform neurofibroma being the uncommon variant of neurofibroma generally involves head and neck region. It arises from the proliferation of all neural elements. Presence of this tumor at lower extremity is highly uncommon and involves lots of complications. In this study we have taken highly vascular nature of the tumor in consideration and done prior histopathological confirmation along with immunohistochemistry marker to confirm the diagnosis. Proper prior examination involved radiological screening and colored Doppler investigations. Previous failed surgery of patient marked into the importance of present concern regarding the surgery. Uncommonly, a plexiform neurofibroma may change into a cancer, called a malignant peripheral nerve sheath tumor (MPNST). There are no reliable tests to screen for an MPNST. Thus surgery was performed and specimen has been sent to histopathology. Diagnosis was confirmed with the help of IHC and patient was discharged after recovery from surgery.

Keywords: Plexiform neurofibroma, Nerve sheath tumor, neurofibromatosis type I, Schwann cell tumor, CD34 marker

Medical Science, 2021, 25(111), 1084-1087

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