Volume 25, Issue 110, April, 2021

Obesity as a threshold of elevating insulin and leptin: A population based cross sectional study

Samananda L^♦, Govindaraj Y, Kanan W

Department of Physiology, Regional Institute of Medical Sciences, Manipur, India

^♦Corresponding author
Department of Physiology, Regional Institute of Medical Sciences, Manipur, India; Email: nanaomeitei@gmail.com

ABSTRACT

Obesity is often thought to be the result of excessive calorie intake and lack of energy expenditure that leads to negative health impacts such as type 2 diabetes, cardiovascular problems, cancers and other metabolic disorders. Study aimed to evaluate the levels of insulin and leptin in non-obese and obese and its relationships. A total of 331 individuals, age 18 to 65 years (female 212 and male 119) were involved in the study which was conducted in the department of Physiology, Regional Institute of Medical Sciences, Imphal, Manipur, India. Collected blood samples were estimated insulin and leptin levels. All data were calculated the correlations between insulin and leptin. Present study showed significant changes of insulin and leptin levels (P < 0.01) among non-obese and obese. Males were found significant increase (P < 0.01) in insulin levels as compared to female non-obese and obese group. In contrast, female showed higher leptin levels significantly than male groups of non-obese and obese. Data presents positive correlations between BMI and insulin (P < 0.05) as well as between BMI and leptin (P < 0.01). Insulin levels had positive relationships with leptin levels (P < 0.05) in the obese group. We conclude that with increasing insulin and leptin levels in obese, probability to prone prediabetic and other metabolic disorders might high.

Keywords: Insulin, Leptin, Obese, Manipur

Medical Science, 2021, 25(110), 853-858

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