Volume 25, Issue 109, March, 2021

Statins induced transaminitis in Iraqi patients with dyslipidemia

Thuraya Salim Abed¹, Gheyath Al Gawwam², Hayder A Fawzi^3♦

¹Baghdad Medical city, Ministry of health, Baghdad, Iraq
²College of Medicine, Baghdad University, Baghdad, Iraq
³Department of pharmacy, Al Rasheed University College, Baghdad, Iraq

^♦Corresponding author
Department of pharmacy, Al Rasheed University College, Baghdad, Iraq; Email: hayder.adnan2010@gmail.com

ABSTRACT

Objective: assess the effect of using statins on liver enzymes in patients with dyslipidemia. Methods: A prospective observational study, the study involved 140 participants that were initiated on statin therapy at the end of the study 104 patients completed the study. Age of the patients ranged from 35 – 74 years. All patients examined after 6 months to assess the elevation in aminotransferase and bilirubin levels. Results: After 3 and 6 months; there was a significant elevation of serum AST, ALT, and bilirubin. However only 2.9% and 3.8% of the patients had an elevation (more than 2 upper normal limit) in serum AST and ALT respectively. The most common side effect was muscle ache. Conclusions: statins is appear to safe drug, despite there an elevation in some of liver enzymes in this study this elevation is mostly biochemical in natural. In term other side effect statins showed good tolerability with muscle ache being the most common side effect.

Keywords: statins, liver enzymes, safety, prospective, cohort

Medical Science, 2021, 25(109), 739-743

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