Volume 25, Issue 109, March, 2021

Can immature granulocyte predict the prognosis of bladder cancer?

Osman Barut^1♦, Sefa Resim²

¹MD, Assistant Professor, Sutcu Imam University, Faculty of Medicine, Department of Urology, Kahramanmaras/TURKEY; Email: osmanbrt@hotmail.com; https://orcid.org/0000-0002- 8296-9717
²MD, Professor, Sutcu Imam University, Faculty of Medicine, Department of Urology, Kahramanmaras/TURKEY; Email: sefaresim@gmail.com; https://orcid.org/0000-0003-1652-4792

^♦Corresponding author
Assistant Professor, Sutcu Imam University, Faculty of Medicine, Department of Urology, Kahramanmaras/TURKEY; Email: osmanbrt@hotmail.com

ABSTRACT

Objectives: To determine the diagnostic value of immature granulocyte (IG) count before treatment in patients with invasive bladder cancer and to compare this marker with other routine inflammation markers. Methods: In this retrospective observational study, the data of patients who underwent transurethral resection for the diagnosis of bladder cancer were analyzed. Two groups were formed as those with non-muscle invasive bladder cancer (NMIBC) and those with muscle invasive bladder cancer (MIBC). Demographic data, routine laboratory tests, neutrophil/lymphocyte ratio (NLR), red blood cell distribution width (RDW), and IG levels of the groups were recorded and compared. Results: There were 57 patients in the NMIBC group and 55 patients in the MIBC group. NLR, RDW and PLR levels were significantly higher in the MIBC group (p<0.001, each). In univariate analysis neutrophil, lymphocyte, NLR, IG, and RDW were identified as predictors for MIBC. In multivariate analysis, NLR, RDW and IG were significantly associated with the predictors of MIBC (p<0.001,each). Cut-off values were 3.06 for NLR, 11.15 for RDW, and 0.08 for IG. Conclusion: IG is an important inflammatory marker included in complete blood count parameters and may be useful in predicting muscle invasion in patients with bladder cancer.

Keywords: Bladder cancer, Immature granulocyte, Neutrophil-lymphocyte ratio, Red blood cell distribution width

Medical Science, 2021, 25(109), 723-729

PDF