Volume 25, Issue 107, January, 2021

Nephroprotective mechanisms, therapeutic potential and perspective on melatonin use for drug-induced nephropathy

Yevheniia Dudka, Igor Zamorskii, Tetiana Shchudrova^♦, Anatoliy Petriuk, Tamara Kopchuk, Vira Drachuk

Higher State Educational Establishment of Ukraine “Bukovinian State Medical University”, Chernivtsi, Ukraine

^♦Corresponding author
Higher State Educational Establishment of Ukraine “Bukovinian State Medical University”, Chernivtsi, Ukraine; Email: tshchudrova@gmail.com

ABSTRACT

The research aimed to review the effects and mechanisms of action of the pineal hormone melatonin, to study the nephroprotective effect of exogenous melatonin in conditions of drug-induced nephropathy, and to assess the prospects of its use for prevention and treatment of kidney diseases based on the literature data and results of own studies. According to literature and results of our previous research, the nephroprotective effect of melatonin has been shown in various experimental models of acute renal injury (AKI). Numerous studies established the antioxidant, anti-inflammatory, anti-apoptotic, immunomodulatory, and cytoprotective effects of melatonin, and showed its ability to restore the function and structure of the kidneys. The objective of the current study was to evaluate the effects of melatonin (5 mg/kg) on the animal model of acetaminophen-induced AKI. The obtained results show the ability of melatonin to reduce the severity of damage and prevent kidney dysfunction associated with acetaminophen over dose. Treatment with melatonin was suppressed the progression of oxidative stress in kidney tissue through the limitation of lipid and protein peroxidation and activation of the key antioxidant enzymes. Results of research complement to existing data on the nephroprotective activity of melatonin and substantiate the high therapeutic potential and prospects of melatonin use as adjunctive therapy of drug-induced nephropathy.

Keywords: drug-induced nephropathy, melatonin, nephrotoxicity, nephroprotection

Medical Science, 2021, 25(107), 163-169

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