Volume 24, Issue 106, November - December, 2020

Pediatric salivary gland malignancy: NCI experience

Abdalwahab R Abdalwahab^1♦, Ghobrial R.E¹, Mai Gad², Mamdouh Mahmoud Mostafa³, Reham Mohamed Gamal³, Mostafa Selim⁴, Mohamed H Zedan¹

¹Department of surgical oncology, National cancer institute, Cairo University, Egypt
²Department of surgical pathology, National cancer institute, Cairo University, Egypt
³Department of anesthesia, ICU & pain management, National cancer institute, Cairo University, Egypt
⁴Department of pediatric oncology, National cancer institute, Cairo University, Cairo University, Egypt

^♦Corresponding author
Department of surgical oncology, National cancer institute, Cairo University, Egypt, Email: abdalwahab.raafat@gmail.com

ABSTRACT

Background: Salivary glands malignancies are not common among pediatric populations less than 16 years old. These tumors represent less than 10% of head and neck tumors among pediatric population. Pediatric parotid malignancies represent most of them with mucoepidermoid carcinoma as the most common malignant variant. Methods: This study is a retrospective cohort study included 32 pediatric patients with major salivary glands lesions who were treated and followed up at the National cancer institute, Cairo University, from January 2008 to January 2018, The primary end point for this study is to present our institutional experience with the evaluation and management of pediatric major salivary glands malignant tumors, and to evaluate the incidence types, presentation, imaging characteristics, pathological features and treatment outcomes of pediatric major salivary glands malignant tumors. Results: The median age of the patients was 10 years old (range: 2 – 13 years), 13 cases (40.6%) were female and 19 cases (59.37%) were male, investigations were done for all patients in the form of radiological and pathological investigations; radiological workup was CT & MRI in 2 cases (6.25%), ultrasound & CT in 30 cases (93.75%); pathological workup was FNAC alone in 26 cases (81.25%), FNAC and true cut biopsy in 6 cases(due to inadequate FNAC) (18.75%), 14 cases (43.75%) were in the left parotid gland, 2 cases (6.25%) were in the left submandibular gland, 14 cases (43.75%) were in the right parotid gland and 2 cases (6.25%) were in the right submandibular gland. Pathological results; mucoepidermoid carcinoma in 19 cases (59.37%), adenoid cystic carcinoma in 4 cases (12.5%), Hodgkin lymphoma in 2 cases (6.25%), rhabdomyosarcoma (anaplastic variant) in 2 cases (6.25%), rhabdomyosarcoma (embryonal variant) in 4 cases (12.5%) and acinic cell carcinoma in 1 case (3.1%). Conclusion: Among 32 pediatric patients with malignant salivary neoplasms, parotid gland represented the most common site for these tumors (87.5%), mucoepidermoid carcinoma represented the most common variant (59.37%).

Keywords: Salivary glands malignancies, mucoepidermoid carcinoma, ultrasound, malignant tumors

Medical Science, 2020, 24(106), 4525-4531

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