Volume 24, Issue 106, November - December, 2020

Potential effect of ferulic acid on NF-κB in a rat model of doxorubicin toxicity

Sameh Abdel Ghany¹, Hala Abdel Malek^2♦, Sahar EL Dakroory³, Amira Kamal El Hawary⁴, Sanad S EL Kholy⁵

¹Lecturer in Clinical Pharmacology, Faculty of Medicine, Mansoura University, Mansoura, Dakahlia, Egypt
²Professor of Clinical Pharmacology, Faculty of Medicine, Mansoura University, Mansoura, Dakahlia, Egypt
³Professor of Forensic Medicine & Clinical Toxicology, Faculty of Medicine, Mansoura University, Mansoura, Dakahlia, Egypt
⁴Professor of Medical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Dakahlia, Egypt
⁵Lecturer in Medical Physiology, Faculty of Medicine, Kafr El Sheikh University, Kafr El Sheikh, Egypt

^♦Corresponding author
Professor of Clinical Pharmacology, Faculty of Medicine, Mansoura University, Mansoura, Dakahlia, Egypt; Email: halamalek@live.com

ABSTRACT

"Adricin" or Doxorubicin (Dox) is an anthracycline antibiotic agent used in the treatment of solid and haematopoietic tumors, but it has cardiac, renal and hepatic toxicities. Oxidative stress has an important role in the pathogenesis of Dox- toxicity. This study investigated the role of Ferulic acid (FA), a natural antioxidant agent, in protection against Doxorubicin-induced toxicity. 40 albino rats were used, and divided into four groups, Group I (control group), Group II: Dox intraperitoneal for two weeks. Group III: Ginkgo biloba (GB) + Dox, Group IV: FA +Dox. Biochemical assays for serum creatinine, serum lactate dehydrogenase, creatine phosphokinase, AST and ALT were done. Immuno histochemistry examination of the kidneys, heart and liver and the levels of MDA, GSH, SOD and catalase were assessed. Results: Treatment with FA resulted in improvement of oxidative stress, and decrease in expression of NF-κB, that may be a promising natural adjuvant therapy, potentially ameliorating Dox toxicity in clinical practice. Conclusion: FA can be considered a good candidate for offering protection against the deleterious toxicity of Dox.

Keywords: Dox toxicity, Ferulic acid, Doxorubicin, Oxidative stress

Medical Science, 2020, 24(106), 4321-4331

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