Volume 24, Issue 106, November - December, 2020

Polyradiculoneuropathy, Organomegaly, Endocrinopathy, Monoclonal Plasma Cell Disorder, and Skin Changes (POEMS) Syndrome: A case report

Raneem Alraheili^1♦, Turki Alwasaidi²

¹College of Medicine, Taibah University, Al Madinah, Saudi Arabia
²Hematology Division, Medicine Department, Prince Mohammed Bin Abdulaziz Hospital, Ministry National Guard - Health Affairs, AL Madinah, Saudi Arabia - Medicine Department, College of Medicine, Taibah University, AL Madinah, Saudi Arabia.

^♦Corresponding author
College of Medicine, Taibah University, Al Madinah, Saudi Arabia; Email: dr.raneemalraheili@gmail.com

ABSTRACT

Polyneuropathy, Organomegaly, Endocrinopathy, M Proteins, and Skin changes (POEMS) syndrome is a rare type of plasma cell dyscrasia. It is a paraneoplastic syndrome with multiple systemic manifestations. Diagnosis of POEMS syndrome is commonly challenging, due to its multisystemic involvement and its rarity. This case report described a 60 year old female patient who suffered from POEMS syndrome. The patient’s symptoms were complicated. Initially, she was misdiagnosed as pulmonary tuberculosis. Subsequently, POEMS syndrome has been diagnosed based on clinical features and laboratory findings. After the diagnosis of POEMS syndrome, she treated with lenalidomide – dexamethasone regimen. The patient completed seven cycles with a significant response followed by a high dose of melphalan chemotherapy with autologous hematopoietic stem cell transplantation as consolidation therapy.

Keywords: Polyradiculoneuropathy; Organomegaly; Endocrinopathy; Monoclonal plasma cell disorder; Skin changes

Medical Science, 2020, 24(106), 3874-3880

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