Volume 24, Issue 106, November - December, 2020

Study of the common variant rs9939609 of FTO gene polymorphism in Polycystic Ovary Syndrome

Wessam El Sayed Saad^1♦, Aziza Ahmed El Sebai², Maram Mohamed Maher³, Alaa Mahmoud Heikal⁴

¹Associate Professor of Clinical and Chemical Pathology, Faculty of Medicine, Ain shams University, Cairo, Egypt; Email: dr.wessamelsayed@gmail.com
²Professor of Clinical and Chemical Pathology, Faculty of Medicine, Ain shams University, Cairo, Egypt; Email: azizaelsebai@gmail.com
³Professor of Internal Medicine, Diabetes and Endocrinology Faculty of Medicine, Ain Shams University, Cairo, Egypt; Email: maramromia@hotmail.com
⁴Master degree, Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Cairo, Egypt; Email: alaa.hekal@live.com

^♦Corresponding author
Associate Professor of Clinical and Chemical Pathology, Faculty of Medicine, Ain shams University, Cairo, Egypt; Email: dr.wessamelsayed@gmail.com

ABSTRACT

Background: Genes associated with obesity might play a role in pathogenesis of PCOS such as fat mass and obesity associated (FTO) gene. Objective: To investigate the association between the common variant rs9939609 of FTO gene with PCOS in Egyptian women in respect to obesity and insulin resistance. Methods: This study was conducted on (50) Egyptian female patients diagnosed as PCOS according to the criteria of Rotterdam Revised (2003) (Group I, patients) and (50) age-matched apparently healthy females (Group II, controls). PCOS patients were classified according to obesity as well as insulin resistance. Detection of FTO rs9939609 polymorphism was done by real time polymerase chain reaction. Results: This study revealed a significant difference between group I and group II as regards FTO genotypes A/A, A/T and T/T with increase in frequency of A/T and T/T genotypes in PCOS patients (56% A/T and 8% T/T) compared with controls (4% and 0%; respectively). Conclusion: FTO gene variant rs9939609 is associated with PCOS susceptibility in Egyptian women. The association has been demonstrated in both obese and non-obese patients as well as in PCOS patients with insulin resistance and non-insulin resistance.

Keywords: FTO, Single nucleotide polymorphism, rs9939609, PCO

Medical Science, 2020, 24(106), 3845-3854

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