Volume 24, Issue 105, September - October, 2020

Malignant Brenner Tumor- A rare case of ovarian carcinoma

Shikha M. Toshniwal¹, Saunitra A. Inamdar², Himanshi D. Agarwal³, Sakshi R. Sharma⁴

¹Junior Resident, Department of Obstetrics and Gynaecology, Jawaharlal Nehru Medical college, Datta Meghe Institute of medical sciences(Deemed University), Sawangi Meghe, Wardha, Maharashtra, India; Email: shikhatoshniwal802@gmail.com
²Professor, Department of Obstetrics and Gynaecology, Jawaharlal Nehru Medical college, Datta Meghe Institute of medical sciences (Deemed University), Sawangi Meghe, Wardha, Maharashtra, India; Email: saunitrainamdar56@gmail.com
³Junior Resident, Department of Obstetrics and Gynaecology, Jawaharlal Nehru Medical college, Datta Meghe Institute of medical sciences(Deemed University), Sawangi Meghe, Wardha, Maharashtra, India; Email: hagarwal2701@gmail.com
⁴Junior Resident, Department of Obstetrics and Gynaecology, Jawaharlal Nehru Medical college, Datta Meghe Institute of medical sciences(Deemed University), Sawangi Meghe, Wardha, Maharashtra, India; Email: s.sakshisharma22@gmail.com

ABSTRACT

Ovarian cancer are a heterogenous group of tumors, involving a variety of histological tissue ranging from epithelial tissue, connective tissues, specialized hormone secreting cells to germinal and embryonal cells. Brenner Tumor’ (BT) is a rare epithelial ovarian tumor accounting for about 1-2% of all ovarian neoplasms. Malignant Brenner tumor (MBT) is much rarer. Although asymptomatic, they can presents as abdominal discomfort, abdominal pain or abnormal uterine bleeding. On gross appearance, it resembles fibroma of ovary with cut section appearing gritty and yellowish grey. On histological examination, solid and cystic nests of urothelium-like cells surrounded by abundant dense, fibrous stroma are seen. It closely resembles to transitional cell carcinoma of ovary, latter having worse prognosis and needs to be differentiated from Brenner tumor. Currently, most accepted treatment is primary surgical resection with or without lymph node dissection followed by platinum based chemotherapy. We herein review a case of MBT in a postmenopausal woman with abnormal uterine bleeding with emphasis on clinical features, investigations and primary treatment and discuss the current state of the literature and standards of practice regarding this malignancy.

Keywords: ovarian carcinoma, Malignant Brenner tumor, Transitional cell carcinoma

Medical Science, 2020, 24(105), 3550-3554

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