Introduction: Infected non-union of humerus is a chronic disorder, which pose many difficulties to the patient and the surgeon and
the treatment is long term and time consuming. It is one of the most common complications of humerus fractures. Some risk factors
include age, sex, tobacco smoke, metabolic disorders, nutritional deficiencies, fracture type, soft tissue injury, type of surgical
treatment and presence of infection. We present the case of infected non-union in an operated case of compound fracture of shaft
of humerus treated in two stages with Infection control in first stage and then definitive treatment in second stage. Case: A 35 year
old female presented to AVBRH OPD with complains of pain and fullness over right mid-arm who was follow up case of compound
grade II shaft humerus fracture right side and she was managed with ORIF with plating at govt hospital in Chandrapur 9 months
ago. On examination, tenderness and abnormal mobility was present at fracture site, overhead abduction and forward flexion was 90
degrees and further movements were painful and restricted. The radiograph showed Non-Union of mid-shaft of humerus with
implant in situ. The patient, in first stage was managed with Debridement of Non-Union site and Sinus tract excision and insertion of
Calcium sulphate antibiotic (Vancomycin) beads at and around the fracture site. Postoperatively, patient’s arm was immobilized by
above elbow slab. The pus culture shows No growth. Patient continued having copious amount of discharge from the wound for
around 2-3 weeks and suture removal was done after 3 weeks of surgery. Patient was continued on antibiotics for 6 weeks. On
follow up at 6 weeks, wound was completely healed and discharge was absent and the pain and swelling was reduced but still the
tenderness and abnormal mobility at fracture site was present. Functional humerus brace with mobilization of shoulder, elbow, wrist
and fingers was advised with continuation of antibiotics. Then the patient was recalled after 6 weeks for definitive treatment. After 6
weeks, the patient was managed with removal of old plate and ORIF with LCDCP with cancellous bone grafting. Then the patient was
discharged with continuation of functional humerus brace application and finally showing an excellent outcome. Conclusion: The
treatment of humerus-infected non-union is a challenge for the orthopedic surgeon. The use of an antibiotic-impregnated bead,
associated to systemic antibiotic therapy, is a valid option of treatment.
Keywords: Non-Union, Humeral shaft fracture, Limited-Contact Dynamic Compression Plate (LCDCP).