Background and Aim: Early enamel caries in primary dentition are highly prevalent and conservative treatments are needed at this
stage. Considering the structural differences between primary and permanent teeth, this study aimed to compare the microhardness
of early enamel lesions of deciduous teeth, treated with an infiltrant resin, a fluoride varnish and GC Tooth Mousse. Materials and
Methods: Thirty six intact primary canines were included in the present in-vitro study. They were immersed in a demineralizing
solution and incubated at 37ยบ C for 4 days. The samples were randomly assigned into three study groups (rein infiltrate (group 1),
GC Tooth Mousse (group 2) and fluoride varnish (group 3); 12 samples within each) and differently treated. Microhardness was
evaluated before and after the remineralization process and after treatments for each specimen using a Vickers hardness testing
machine. Data analysis was performed using paired T test on SPSS v22 software. Results: In group 2, the microhardness coefficient
was increased significantly (P=0.04) from 133.3 to 155.4 (+22.1 V). The microhardness coefficient for group 1 was increased, but not
significantly, (P=0.2) from 139.7 to 152.4. In group 3, the microhardness coefficient was significantly (P= 0.001) increased from 138.6
to 178.3 (+39.7 V). Conclusion: The resin infiltrate enhanced the surface microhardness, but not significantly. The fluoride varnish and
the tooth mousse both increase the surface microhardness of enamel by improving the remineralization process.
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