Background: Chronic Obstructive Pulmonary Disease (COPD) is a condition characterized by inflammation and narrowing of the
lungs' airways and damaged air sacs. It is a major preventable and treatable public health problem around the globe. The study
aimed to identify risk factors associated with Chronic Obstructive Pulmonary Disease among adults. Subject and methods: A total of
314 participants (157 Cases (COPD) and 157 controls) were randomly selected in a case-control study conducted in Arar
City, Northern Border Province, Saudi Arabia in the period from January 2019 to December 2019. Results: Risk factors with significant
differences found between COPD and control groups were gender, age, level of education, residence, socioeconomic status, family
history, smoking passive smoking, and dusty work (P < 0.05). In multivariable analysis, smoking amount and duration, family history
of COPD, history of poorly treated asthma, and age were the only independent factors associated with higher odds of having COPD.
Conclusion: The results of this study showed that amount and duration of smoking not just smoking alone were important risk
factors of COPD.
Keywords: Chronic, Obstructive, Pulmonary, Disease, smoking