Volume 24, Issue 104, July - August, 2020

Comparing serum leptin levels between pregnant women with preeclampsia and normal pregnant women

Narjes Noori¹, Maryam Nurzadeh², Taraneh Arbabzadeh³, Asma Narouii⁴, Mahnaz Shahrakipour⁵, Marzieh Ghasemi^1,6♦

¹Department of Obstetrics and Gynecology, Pregnancy Health Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
²Department of Fetomaternal, Faculty of Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
³Department of Obstetrics and Gynecology, Assistant of Perinatology, Tehran University of Medical Sciences, Tehran, Iran
⁴General Practitioner and Researcher, Zahedan University of Medical Sciences, Zahedan, Iran.
⁵Department of Biostatics and Epidemiology, School of Public Health, Zahedan University of Medical Sciences, Zahedan, Iran
⁶Mouloud Infertility Center, Ali Ibn Abitaleb Hospital, Zahedan University of Medical Sciences, Zahedan, Iran

^♦Corresponding author
Marzieh Ghasemi; Department of Obstetrics and Gynecology, Pregnancy Health Research Center, Zahedan University of Medical Sciences, Zahedan, Iran, Mouloud Infertility Center, Ali ibn Abitaleb Hospital, Zahedan University of Medical Sciences, Zahedan, Iran, Email: drghasemim@yahoo.com, Tel: +98 54 3229 5715

ABSTRACT

Objective: Serum leptin, the product of the obesity gene, correlates with adiposity and increases fat utilization. Maternal serum leptin, triglyceride and free fatty acids are elevated in healthy pregnancy, and are increased further in preeclampsia. This study has compared serum leptin levels in pregnant women with preeclampsia and normal pregnant women. Materials and Method: This casecontrol study was done in 2018 on eighty pregnant women of a hospital in Zahedan city, Iran. Forty of the chosen women had preeclampsia (case group) and the rest were normal (control group). Serum leptin level was measured by enzyme-linked immunosorbent assay test and analyzed using the t-test. Results: The leptin levels were 1985 pg/mL and 2595 pg/mL in case and control groups which was significantly different (P = 0.016). Leptin level had no significant correlation with age, preeclampsia history or blood pressure (P > 0.05). Also, leptin levels increased with increase of body mass index in pregnant women with preeclampsia (P = 0.029). Conclusion: We found that the blood leptin levels were significantly lower in the preeclampsia group compared with the normal pregnant women. Measuring blood leptin levels, BMI and Systolic blood pressure in pregnancy may be helpful as early tests in the early detection of high risk individuals.

Keywords: preeclampsia; pregnancy; leptin; Maternal: healthy pregnancy

Medical Science, 2020, 24(104), 2273-2279

PDF