Volume 24, Issue 104, July - August, 2020

Treatment of respiratory distress syndrome in premature infants: A comparison of LISA and INSURE methods in the Vietnamese context

Xuan Minh Ngo^1♦, GiangThi Cam Le²

¹Faculty of Medicine, Pham Ngoc Thach University of Medicine, Ho Chi Minh city, Vietnam
²Tu Du Hospital, Ho Chi Minh city, Vietnam

^♦Corresponding author
Faculty of Medicine, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam; Email: xuanlien62@pnt.edu.vn

ABSTRACT

Objectives: To explore the clinical effects of less invasive surfactant administration (LISA) with the INSURE (intubation-surfactantextubation) procedure on the treatment of respiratory distress syndrome (RDS) in premature infants. Methods: A total of 206 premature infants with RDS aged 26 to 32 weeks since birth were admitted from August 2017 to July 2018 in Vietnam. In the LISA group, 6F gastric tubes were inserted into the trachea through direct laryngoscopy under nasal continuous positive airway pressure (NCPAP), and pulmonary surfactant (PS) was injected. In the INSURE group, PS was injected via tracheal intubation and NCPAP was performed after extubation. The incidence of technical-related adverse events and various complications in the two groups were observed. Results: The mean of gestational age was approximately 29 weeks between the two groups. Infants who were treated with the LISA method showed better indicators, such as change in FiO2 and SpO2, as well as lower incidence of pneumonia or death. The less invasive surfactant pump group had a shorter hospital stay than the INSURE group. Conclusion: LISA is currently the most suitable method of surfactant administration and should be the first choice in spontaneously breathing infants considering its favorable effects on respiratory morbidities in preterm infants with RDS.

Keywords: infant, INSURE, respiratory distress syndrome, RDS, LISA, Vietnam

Medical Science, 2020, 24(104), 1845-1852

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