Volume 24, Issue 104, July - August, 2020

An assessment of female ovarian cancer patients’ death and survival rates after surgical intervention: Neoadjuvant chemotherapy versus primary debulking surgery

Xuan Minh Ngo^♦, Tro Van Chau

Faculty of Medicine, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam

^♦Corresponding author
Faculty of Medicine, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam; Email: xuanlien62@pnt.edu.vn

ABSTRACT

Objective: The main purpose of the study was to determine the survival and death rates of females with ovarian cancer after undergoing surgical operation. These rates were determined by examining the results from two treatment distinct methods used in females suffering from ovarian cancer. Methods: This retroactive study was conducted at Tu Du Hospital, Ho Chi Minh City, Vietnam, from February to September 2018. The study was associated with the data obtained in 2012 and 2017 about treatments for females suffering from ovarian cancer. The clinical data obtained during the previous analysis was again studied and revised. Similar knowledge was obtained about the environmental, medical, therapeutic, and pathological aspects of the previous studies. Overall existence of patients was compared with growth free existence. Patients who underwent either debulking surgery or neoadjuvant chemotherapy before surgery were compared. Mathematical identification was performed using SPSS. Results: Total 236 patients were undergone surgical cure. Of the total, 66.1% underwent primary debulking surgery; while the remaining 33.9% received neoadjuvant chemotherapy. The average patient age and tumor antigen level (125) before treatment were the same across all patients. In the debulking group, patients were identified according to two stages. One group had 94.8% of patients with stage 3 carcinoma and 5.1% with stage 4 carcinoma. In other groups, the percentage of patients in stage 3 and 4 were 80% and 20%, respectively. The most favorable occurrence of debulking was 56.8% in the earlier group as compared to 79.4% in the second group. At the time of surgery, the total loss of blood was recorded as 1500 ml. The loss of blood was almost the same in the different exhaustive care unit. In addition to the loss of blood, the rate of urinary swathe, bowel grievance, and bowel reactions were also analogous. The growth-free existence was also comparable in both groups. Conclusion: Equivalent existence rates and peri-operative difficulties can be created by neo-adjuvant chemotherapy followed by intermission debulking.

Keywords: Ovarian epithelial cancer, Chemotherapy, Gynecological surgical procedure, Survival analysis

Medical Science, 2020, 24(104), 1839-1844

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