Volume 24, Issue 104, July - August, 2020

Effect of medication non-adherence on Parkinson’s disease psychosis

Wael Gabr^1,2♦, Osama El-Azouni^3,4

¹Associate professor of neurology, Neurology department, Mansoura University, Mansoura, Egypt
²Associate professor of neurology, Internal medicine department, Tiabah University, Madina, KSA
³Associate professor of neurology, Neurology department, Zagazig University, Zagazig, Egypt
⁴Consultant of neurology, Internal medicine department, Mouwasat Hospital, Aljobial, KSA

^♦Corresponding author
Wael M. Gabr, PhD, Department of Neurology, Faculty of Medicine, University of Mansoura, Mansoura Egypt Email: waaael@yahoo.com / wael_gabr@mans.edu.eg

ABSTRACT

Context: medication non-adherence is a common problem among patients with Parkinson's disease, and its effect on the development of non-motor symptoms as Parkinson's disease related psychosis is not fully investigated. Objective: our study aimed at testing the impact of non-compliance on Parkinson's disease psychosis development. Methods: A total of 34 patients with medically recognised Parkinson's disease (26 men and 8 women with an average age of 71.51 ± 6.93 years) were assessed using Parkinson's Psychosis Rating Scale for psychosis identification. The severity of Parkinson's disease was also assessed by Modified Hoehn and Yahr Scale. Morisk adherence scale of medication (MMAS-8) was used to measure patient adherence to medication. Results: In this study, 55.9% of patients with Parkinson's disease were non-adherent to their medication, but non-adherence to medication showed no correlation with the development of Parkinson's disease psychosis (p value 0.853). Conclusions: Nonadherence to medication is not correlated to Parkinson's disease related psychosis and cannot be used as a predictor for its incidence.

Keywords: PD, compliance, adherence, psychosis

Medical Science, 2020, 24(104), 1828-1838

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