Medical Science
Volume 24, Issue 104, July - August, 2020
Impact of Vitamin D on Acute Ischemic Stroke Prognosis (IVASTO)
Mohamed Elsayed Flifel1, Osama A. Abdel Salam1, Mohamed Ameen2, Mohammed Elsherif1♦
1Department of Neurology, Faculty of Medicine, Mansoura University, Egypt
2College of North Atlantic, Newfoundland and Labrador, Canada
♦Corresponding author
Department of Neurology, Faculty of Medicine,
Mansoura University, Egypt;
Email: elsherifmohammed@mans.edu.eg
ABSTRACT
Background and Purpose: The correlation between acute ischemic stroke (AIS) and Vitamin D (VitD) was reported in many
observational studies. This study aimed to investigate this association, the severity, and the short term outcome of AIS patients with
different VitD levels. Methods: The patients were assessed at the onset by clinical and severity scores {National Institutes of Health
Stroke Scale (NIHSS), modified Rankin Scale (mRS)}. In follow-ups after 3 months they were assessed by mRS and were classified
according to VitD levels into control group 1(≥ 30 ng/ml) and abnormal group 2 (VitD < 30 ng/ml). Comparison and correlation of
the VitD in AIS, NIHSS, and mRS were calculated between both groups. Results: The present single-center prospective crosssectional
study during one-year duration was done on 59 patients with AIS. Vascular risk factors did not show any differences
between both groups (P > 0.05). It showed statistically significant differences between both groups regarding VitD level, NIHSS, mRS
after 3 months with P-value < 0.001, 0.0035, and 0.0167 respectively. There is a negative correlation between VitD level and NIHSS
scores, VitD level and mRS scores at the onset, and after 3 months P < 0.0001, < 0.0001, < 0.00 respectively. Conclusion: AIS patients
with VitD deficiency showed more stroke severity and poor outcomes. The VitD serum level should be examined as supplementation
may have an important role in the guidelines of cerebral stroke treatment.
Keywords: acute ischemic stroke, Vitamin D, NIHSS, modified Rankin Scale
Medical Science, 2020, 24(104), 2001-2008
