Medical Science
Volume 24, Issue 104, July - August, 2020
Effect of magnetic nanoparticles on Ehrlich solid tumor in mice using thermal ablation
Salim M.A. El Hamidy1,2
1Department of Biological Sciences, Faculty of Sciences, King Abdulaziz University, Jeddah, Saudi Arabia
2Princess Dr Najla Bint Saud Al Saud Center for Excellence Research in Biotechnology, King Abdulaziz University, Jeddah, Saudi
Arabia
ABSTRACT
Recently, nanotechnology plays a significant role in cancer prohibition and treatment. Various kinds of iron oxide are naturally
occurring and may be synthesized under laboratory conditions. This research was intended to estimate the histological and
biochemical changes induced by Ehrlich Solid Carcinoma (ESC) in the skeletal muscle of mice treated with Epirubicin, and Fe3O4/MPA
NPs with hyperthermia. The experimental animals were equally allocated into 4 groups (50 mice/group). Mice of the first group were
benefit as normal control. The second group were intramuscularly injected with ESC. The ESC affected mice of the third and fourth
groups were treated with Epirubicin and Fe3O4/MPA NPs with hyperthermia, respectively. The present investigations displayed that
treatment of ESC mice with Epirubicin and Fe3O4 NPs/MPA revealed a significant reduce (P ≤ 0.05) in the creatinine kinase (CK),
aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activity. The histological changes in the skeletal muscles in the
first treated group showed reduction of cancer cells, cirrhosis and destruction of tissue cells, also, the group administrated by
Fe3O4/MPA with hyperthermia showed disappearance of a large number of cancer cells compared to the first group of treatment
and the return of life to the fabric affected without touching or affecting the normal cells of the tissue. In conclusion, the in vivo
cancer treatment test could cure the cancer tumor, protecting the skeletal muscle tissues and ameliorated CK, AST and ALT enzyme
activity.
Keywords: Histopathology, Magnetic nanoparticles, biochemical parameters, Hyperthermia, Ehrlich, Cancer
Medical Science, 2020, 24(104), 1942-1950
