Volume 24, Issue 103, May - June, 2020

A comparative study on the effect of denture adhesive containing ordinary particles and nanoparticles of zinc Oxide against Candida albicans

Ladan Jamshidy^♦, Fatemeh Jafari

Department of Prosthodontics, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran

^♦Corresponding author
Ladan Jamshidy, Department of Prosthodontics, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran

ABSTRACT

Background: Using denture adhesives is the most common method to increase denture retention. However, their Chronic use may be accompanied with complications like Candida Stomatitis caused by Candida albicans. Combining the adhesives with Zinc Oxide as an antifungal drug has been recently widespread in the products. Objectives: Determining effective concentrations of particles and nanoparticles of Zinc Oxide in combination with denture adhesive for preventing growth of C. albicans through preparing broth media mixed with Zinc Oxide, either particle or nanoparticle, and denture adhesive in different concentrations in order to culture C. albicans, and recording the lowest concentrations which the growth of C. albicans was prevented. Material and Methods: broth media mixed with increasing concentrations of Zinc Oxide (particle and nanoparticle) and denture adhesive were prepared through serial dilution for three experiments. Culturing the incubated tubes, which were contaminated with C. albicans, on Sabouraud dextrose agar medium determined those concentrations which prevented the growth of C. albicans. Results: the growth of C. albicans was prevented at 50 μg/mlZinc Oxide nanoparticles, whereas the growth was prevented at 200 μg/ml Zinc Oxide particle. Conclusions: Both types of Zinc Oxide have fungicidal properties in presence of denture adhesive, but the nanoparticle kill more effectively the pathogen. Combining denture adhesives with nanoparticles of ZnO is suggested.

Keywords: Candida albicans, denture stomatitis; fungal infections; nanoparticles; Zinc Oxide

Medical Science, 2020, 24(103), 1725-1730

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