Volume 24, Issue 103, May - June, 2020

Alteration in pancreas of rats treated with individual and combined food additives

Sara S Moen¹, Manal EA Elhalwagy^2,3, Najla O Ayaz²

¹Department of Biochemistry, Faculty of Science-Al Faisaliah Campus, King Abdulaziz University, Jeddah, Saudi Arabia
²Department of Biochemistry, College of Science, University of Jeddah, Saudi Arabia
³Department of Mammalian Toxicology, Pesticide Central Laboratory, Agriculture Research Center, Giza 12618, Egypt

ABSTRACT

The impact of individual and combined treatment of artificial food additives on oxidative stress, antioxidant parameters and pancreatic disruptor in male albino rats will be examined in this study. Six groups of young albino rats (80 - 100 gm) were examined Group I: (Control untreated group), Group II, III, IV and V: treated with ADI of MSG (300 mg / kg), Sodium benzoate (5 mg / kg), Carmoisine (4 m g / kg), and EDTA (2.5 mg / kg) respectively. Group VI: treated with mixture of tested materials simultaneously., The treatments were carried out orally for 28 days. The obtained results revealed production of malondialdehyde MDA and protein carbonyl PC indicators of oxidative stress in individually treated MSG and sodium benzoate and remarkable in mixture group. Significant reduction in catalase, total antioxidant capacity, and glutathione content were recorded in individually treated groups and pronounced in mixture group. Elevation in serum glucose level and alteration in pancreatic enzymes amylase and lipase, as well as insulin, were recorded.

Keywords: Food additives; Oxidative stress; antioxidants; pancreatic enzymes; Insulin

Medical Science, 2020, 24(103), 1544-1552

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