Volume 24, Issue 103, May - June, 2020

Evaluation of changes in cardiac dimensions and functional parameters and their association with anthropometric parameters and laboratory indices in obese adolescents

Mohammad Radgoudarzi¹, Abdolreza Pazouki^2,3, Zahra Fahmfam⁴, Fahimeh Soheilipour^5,6♦

¹Pediatric Cardiologist, Minimally Invasive Surgery Research Center, Iran University of Medical Sciences, Tehran, Iran
²Fellowship of Minimally Invasive Surgery, Minimally Invasive Surgery Research Center, Iran University of Medical Sciences, Tehran, Iran
³Center of Excellence of European Branch of International Federation for Surgery of Obesity
⁴Medical Doctor, Iran University of Medical Sciences, Tehran, Iran
⁵Pediatric Endocrinologist, Minimally Invasive Surgery Research Center, Iran University of Medical Sciences, Tehran, Iran
⁶Pediatric Growth and Development Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran.

^♦Corresponding author
Pediatric Endocrinologist, Minimally Invasive Surgery Research Center, Iran University of Medical Sciences, Tehran, Iran; Email: soheilipour.f@iums.ac.ir

ABSTRACT

Background: Due to physiological and metabolic adaptation related to obesity, the pathological changes in cardiovascular geometry and functional state are expected. The purpose of this study was to evaluate asymptomatic alterations in cardiac dimensions and functional parameters and their association with anthropometric parameters and other laboratory indices in obese adolescents. Material and Methods: This study is a cross-sectional trial performed on 23 obese adolescents and 23 sex and age-matched healthy non-obese adolescents randomly selected from the relatives of hospital personnel. All individuals were undergone tissue Doppler echocardiography and transthoracic echocardiography to determine the cardiac parameters. Results: Obese patients had significantly higher mean left atrial area and volume, mean E and A velocities, declaration time, septal thickness, diastolic interventricular, left ventricular mass, end-diastolic left ventricular posterior wall thickness, epicardial adipose tissue thickness, and relative wall thickness but adversely had lower stroke volume and left ventricular ejection fraction. The raised LDL level was directly associated with A velocity. Also, serum triglyceride level was positively associated with left ventricular mass and left atrial volume, but adversely related to left ventricular ejection fraction. Conclusion: Obese adolescents are expected to experience significant changes in diastolic geometry and left ventricular wall dimensions. These changes can be closely associated with altered lipid metabolism.

Keywords: Cardiac dimensions, Functional parameters, Anthropometric parameters, Laboratory indices, obese adolescents

Medical Science, 2020, 24(103), 1520-1527

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