Volume 24, Issue 103, May - June, 2020

Pemphigus foliaceus mimicking acute cutaneous lupus: A case report

Khalid Al Hawsawi^1♦, Anas Tayebi², Suha Alsayed³, Shahad Alkidaiwi³, Abdulaziz Hussain Abdulmajeed⁴, Abdulelah Hassan Alluhaybi⁵

¹Department of dermatology, King Abdulaziz hospital, Makkah, Kingdom of Saudi Arabia
²Medical Intern, Graduate of the Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia
³Medical Student, Faculty of Medicine, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia
⁴Medical Degree, King Fahad General Hospital, Jeddah, Saudi Arabia
⁵Department of dermatology, King Abdulaziz hospital, Makkah, Kingdom of Saudi Arabia

^♦Corresponding author
Consultant dermatologist, Head of dermatology department, Department of dermatology, King Abdulaziz Hospital, Saudi Arabia; Email: hawsawik2002@hotmail.com

ABSTRACT

Pemphigus foliaceus (PF) is a rare form of pemphigus disease (PD). PD is a chronic autoimmune blistering skin disease. Here we report a case of a 65-year-old female who presented with a 2 months history of persistent slowly progressing painful skin lesions on her face. Skin examination revealed non-scaly, erythematous patches on her face with a butterfly rash distribution. Skin biopsy revealed subcorneal blister with presence of acantholytic keratinocytes in the blister cavity. Intracellular deposition of IgG and C3 in the epidermis was demonstrated using direct immune fluorescence (DIF). Complete blood counts, ESR, blood urea, creatinine, liver function tests, urine examination, ANA, ant d DNA, anti-smith antibodies were all within normal limits. Patient was diagnosed as Pemphigus foliaceus. We started her treatment using prednisolone 20 mg once per day. The lesions disappeared within few weeks of starting the treatment.

Keywords: Senear–Usher syndrome

Medical Science, 2020, 24(103), 1184-1187

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