Volume 24, Issue 103, May - June, 2020

Pattern of change in blood glucose level in hospitalized patient treated with inhaled corticosteroid

Moumita Das^1♦, Tushar Sontakke², Sourya Acharya³, Samarth Shukla⁴

¹MBBS student, Datta Meghe Institute of Medical Sciences (deemed to be university), J.N. Medical College, ABVR Hospital, Sawangi Meghe, Wardha 442001, Maharashtra; Email: aisharay07@gmail.com
²Asst. Professor, Dept. of Medicine, Datta Meghe Institute of Medical Sciences (deemed to be university), J.N. Medical College, ABVR Hospital, Sawangi Meghe, Wardha 442001, Maharashtra; Email: tushar.ihmp@gmail.com.
³Professor, Dept of Medicine, Datta Meghe Institute of Medical Sciences (deemed to be university), J.N. Medical College, ABVR Hospital, Sawangi Meghe, Wardha 442001, Maharashtra; Email: souryaacharya74@gmail.com.
⁴Professor, Dept of Pathology, Datta Meghe Institute of Medical Sciences (deemed to be university), J.N. Medical College, ABVR Hospital, Sawangi Meghe, Wardha 442001, Maharashtra; Email: samarth21174@gmail.com.

^♦Corresponding author
MBBS student, Datta Meghe Institute of Medical Sciences (deemed to be university), J.N. Medical College, ABVR Hospital, Sawangi Meghe, Wardha 442001, Maharashtra, India. Email: aisharay07@gmail.com

ABSTRACT

Background: Systemic corticosteroids are used to treat bronchial asthma and COPD. It is known that corticosteroid alters blood sugar level. In addition inhaled corticosteroids promote gluconeogenesis by direct hepatic stimulation and also by increasing resistance to insulin. However the effect of inhaled corticosteroids on carbohydrate metabolism is comparatively lesser and systemic adverse effects are not as significant as compared to oral or parenteral routes. This study was conducted to assess the effect of inhaled corticosteroids on blood sugar level in COPD and asthma patients taking inhaled corticosteroids (ICSs). Aim: To study the pattern of change in blood glucose level in hospitalized patient while on treatment with inhaled corticosteroid. Method: This cross sectional study was conducted in Jawaharlal Nehru Medical College, AVBRH hospital, Wardha. After taking clearance from the Institutional ethical committee, 45 cases of bronchial asthma and COPD were selected. Frequency and dosing of corticosteroid was evaluated, along with evaluation of fasting and post prandial glucose. Result: In this study we found that as the dose of inhaled corticosteroid increased , fasting blood sugar and post meal blood sugar were altered in higher doses of corticosteroids (p=0.00). Significant difference in the blood sugar value were found in fasting and postprandial state with dose less than 600 ug/day and in dose between 600 to 1200 ug/day .Mean value in fasting state was 98 mg/dl (SD 4.47) with a dose less than 600 ug /day and mean value of blood sugar was 110.2 mg/dl (SD 4.43) with dose of 600 to 1200 ug /day. As the frequency of dose increased, fasting and post meal blood sugar values were also increased in a linear correlation (p<0.05) which is significant. Conclusion: This study hence shows that there is a positive correlation between inhaled corticosteroid and blood sugar levels, with increasing dose the fasting and post meal blood sugar level increases in non diabetic individuals. Therefore it is necessary to keep a check on a regular basis of blood sugar in hospitaised patients taking inhaled corticosteroids.

Keywords: Bronchial asthma, COPD, Inhaled corticosteroids, Hyperglycemia

Medical Science, 2020, 24(103), 1122-1127

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