Volume 24, Issue 102, March - April, 2020

Clinical profile of Uremic polyneuropathy in Chronic Kidney Disease patients

Parag Aradhey¹, Anand Bakre^2♦, Sunil Kumar³, Sourya Acharya⁴

¹Senior Resident, Department of Medicine, Jawaharlal Nehru Medical College, Sawangi, DMIMS (DU) Sawangi (M) Wardha Maharashtra ²Assistant Professor, Department of Medicine, Jawaharlal Nehru Medical College, Sawangi, DMIMS (DU) Sawangi (M) Wardha Maharashtra ³Professor & Head, Department of Medicine, Jawaharlal Nehru Medical College, Sawangi, DMIMS (DU) Sawangi (M) Wardha Maharashtra ⁴Professor, Department of Medicine, Jawaharlal Nehru Medical College, Sawangi, DMIMS (DU) Sawangi (M) Wardha Maharashtra

^♦Corresponding author
Assistant Professor Department of Medicine, JNMC Sawangi, Datta Meghe Institute of Medical Sciences, (Deemed University), Sawangi, Wardha, Maharashtra, India Email: dranandbakre@gmail.com

ABSTRACT

Objective: To study the clinical and electrophysiological features of peripheral neuropathy in chronic kidney disease (CKD) patients. Methods: Present study was conducted from January 2018 and December 2018 in which 40 recently diagnosed CKD patients undergoing haemodialysis for one year and 40 controls were included. Results: In present study prevalence of uremic polyneuropathy was 50% based on clinically and electrophysiological studies showed prevalence of 65%. Mean age of 40 cases was 36.9 ± 12 years. 26 (65%) were male and 14 (35%) were female. All patients were recently diagnosed CKD on haemodialysis since less than 1year duration. Patients having Diabetes and other co-morbid conditions contributory to neuropathy were excluded. Positive and negative sensory symptoms were seen in 15(37.5%), 10(25%) patients respectively. In present study 16 (40%) patients had mild to moderate neuropathy and 4(10%) had severe neuropathy according to modified NDS score. Most common nerves involved were peroneal, sural & tibial nerve. The most common pattern of uremic polyneuropathy was Axonal mixed sensory motor type. Conclusion: Peripheral neuropathy is common in CKD patients causing significant morbidity at very early stage and many patients can have subclinical neuropathy which can be assessed by electrophysiological study.

Keywords: Chronic Kidney Disease, Uraemia, Haemodialysis, Uremic Polyneuropathy, Nerve Conduction Study

Medical Science, 2020, 24(102), 945-951

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