Medical Science
Volume 24, Issue 102, March - April, 2020
Antibiotic susceptibility of bacterial strains isolated from lower urinary tract infection in 2018 in Zabol: A cross-sectional study
Pardis Nazari1, Hashem Salehimanesh2, Fatemeh Izadpanah3, Mandana Moradi4♦
1Department of Pharmaceutical Biotechnology, School of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran
2Students Research Committee, Zabol University of Medical Sciences, Zabol, Iran
3Laboratory research center of Food &drug administration, IRFDA, MOHME, Tehran, Iran
4Clinical Pharmacy Department, School of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran
♦Corresponding author
Clinical Pharmacy Department, School of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran
Email: mmandana310@gmail.com
ABSTRACT
This study aim was the determining antibiotic sensitivity pattern of most probable pathogens is a major determinant of successful
empiric therapy. A cross-sectional study conducted on 465 patients with UTI. In this study the antibiotic susceptibility pattern of
bacterial strains isolated from lower urinary tract infections was investigated. Bacterial identification and antibiotic sensitivity testing
using disk diffusion method were performed on positive cultures. One hundred and five positive cultures were obtained; 12.4%
males and 87.6% females. Escherichia coli and Staphylococcus spp. were the most common isolated uropathogens. Among E. coli and
S. epidermidis isolates, the highest susceptibility was observed to ciprofloxacin, and the lowest to ampicillin. Four isolates (3.8%) were
susceptible to all tested antimicrobials, and 87 (82.9%) exhibited resistance to at least two different classes of antibiotics. E. coli and
S. epidermidis were major causes of community-acquired UTI in the test society and were resistant to several antibiotics. Based on
these results, ciprofloxacin and Nitrofurantoin were recommended as preferred agents for empiric therapy of UTI.
Keywords: Urinary Tract Infection, Antibiotic Susceptibility Pattern, Uropathogens, Empirical Treatment, Multidrug Resistance
Medical Science, 2020, 24(102), 725-733
