Volume 24, Issue 101, January - February, 2020

Effect of prophylactic intravenous Dexamethasone and Lidocaine on cough and sore throat after extubation in elective laminectomy surgery

Nazli Karami¹, Alireza Mahoori^2♦, Hamid Aghaei³

¹Assistant professor of anesthesiology at Urmia University of Medical Sciences, Urmia, Iran
²Professor of Anesthesiology, Cardiac Anesthesiologist at Urmia University of Medical Sciences, Urmia, Iran
³General Practitioner at Urmia University of Medical Sciences, Urmia, Iran

^♦Corresponding author
Professor of Anesthesiology, Cardiac Anesthesiologist at Urmia University of Medical Sciences, Urmia, Iran Email: ar_mahoori@yahoo.com

ABSTRACT

Context: In spite of advancement in anesthesia and surgery, major operative procedures are accompanied by post-operative complications. Some of them are due to intra-tracheal intubation an inevitable part of anesthesia for patient protection. At the postoperative period, sore throat, cough and hoarseness are more common and distress the patient. Objectives: The aim of this study is to compare the effect of prophylactic intravenous Dexamethasone and Lidocaine on cough and post-operative sore throat after elective laminectomy surgery. Methods and Materials: In this prospective analytic study, 90 adult patients undergoing elective laminectomy surgery were randomly allocated into three groups. The patients received either intravenous 0.1 mg/kg Dexamethasone (group D, n = 30) or 1.5 mg/kg Lidocaine (group L) or normal saline (group P, n = 30) after anesthesia induction and just before intubation with appropriate size of disposable reinforced endotracheal tubes. Follow up for the prevalence of cough and sore throat and its severity was done at 30 min, 1, 6 and 24 hours after extubation. Results: There were no significant differences in demographic data in three groups. In groups D and L, the prevalence of cough and sore throat and it’s severity were significantly less than placebo group (p<0.05) . Regarding the prevalence of cough and sore throat, in comparison of group D with group L, no significant difference was seen (p>0.05). Conclusions: According to results of our study, we can conclude that both prophylactic intravenous Dexamethasone and Lidocaine can reduce the prevalence of post-operative cough, sore throat and it’s severity at the first 24 hours post-extubation period and can be used safely in selective patients.

Keywords: GATS; lidocaine; cough; pharyngitis; dexamethasone, laminectomy

Medical Science, 2020, 24(101), 386-392

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