Volume 24, Issue 101, January - February, 2020

Seroprevalence of HBV and HCV among chronic liver disease patients

Prasant HA, Lalithambigai J^♦, Prabhusaran N, Uma A

Department of Microbiology, Trichy SRM Medical College Hospital and Research Centre, (Affiliated to the Tamilnadu Dr. M.G.R. Medical University, Chennai), Tiruchirapalli, India

^♦Corresponding author
Department of Microbiology, Trichy SRM Medical College Hospital and Research Centre, (Affiliated to the Tamilnadu Dr. M.G.R. Medical University, Chennai), Tiruchirapalli, India Email: leptoprabhu@gmail.com

ABSTRACT

Background: Serological investigation and exact identification procedures are very important to impart the hepatitis infection control in the initial stage itself in order to avoid the major complications including chronic liver damage to successive organ failure. Objective: The main objective of the study is to determine the sero-prevalence of HBsAg, anti HCV antibodies, co-infections of HBV and HCV among clinically diagnosed CLD patients. Methods: A total of 56 subjects were included and all the serum samples were screened for markers of various hepatitis B and C viruses by using ELISA. The observation made out of the study further helped to know the probable mode of transmission and co-infection, so it was guided to follow the proper preventive measures. Results: Out of 56 CLD patients, 21.42% of samples were reactive for HBsAg and 8.92% were reactive for antibodies against HCV. One sample showed reactive for both HBsAg and Anti HCV antibodies. The knowledge of HBV, HCV status of patients provided better status for optimal clinical managements of Chronic liver disease patients to improve the efficacy of therapy, to implement of additional supportive therapy and new drugs, new therapeutic strategies especially vaccination strategies of Hepatitis B. Conclusion: It is a single centre study, limited to 56 subjects, indirect evidence of serology by ELISA using biomarkers only attempted, difficulty in establishing relationships of patient and factors and the transversal studies tend to overestimate the long duration of infections and under estimate the short duration infection.

Keywords: HBV, HCV, CLD, seroprevalence

Medical Science, 2020, 24(101), 335-342

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