Medical Science
Volume 24, Issue 101, January - February, 2020
Assessment of mean platelet volume (MPV) in subjects with Type 2 Diabetes Mellitus (T2DM) in a rural backdrop of central India
Priyal Shrivastava1, Mahalaqua Nazli Khatib2♦, Shilpa Gaidhane3, Dipti Shrivastava4, Abhay M Gaidhane5, Quazi Syed Zahiruddin6
1Jawaharlal Nehru Medical College; Datta Meghe Institute of Medical Sciences (Deemed University)
2Head - Division of Evidence Synthesis; Centre of Excellence School of Epidemiology and Public Health & Professor of Department of
Physiology, Datta Meghe Institute of Medical Sciences (Deemed University), Email: nazli.786@rediffmail.com
3Jawaharlal Nehru Medical College; Datta Meghe Institute of Medical Sciences (Deemed University)
4Jawaharlal Nehru Medical College; Datta Meghe Institute of Medical Sciences (Deemed University)
5Division of Evidence Synthesis; Centre of Excellence School of Epidemiology and Public Health, Datta Meghe Institute of Medical
Sciences (Deemed University)
6Professor of Department of Community Medicine & Division of Evidence Synthesis; Centre of Excellence School of Epidemiology
and Public Health, Datta Meghe Institute of Medical Sciences (Deemed University)
♦Corresponding author
Head, Division of Evidence Synthesis; Centre of Excellence School of Epidemiology and Public Health & Professor of Department of
Physiology, Datta Meghe Institute of Medical Sciences (Deemed University), India
Email: nazli.786@rediffmail.com
ABSTRACT
Diabetes is a public health problem. Altered platelet morphology and function have been reported as a cause of microvascular and
macrovascular complications in patients with diabetes mellitus. We conducted a cross-sectional study to compare MPV in type 2
diabetics (T2DM) and non-diabetics and study the relationship between MPV and glycemic control (HbA1C) in patients with T2DM in
a rural backdrop of central India. Participants were distributed into 2 groups: the study group of patients with T2DM (n = 98) and
control group with non-diabetics (n = 98). The study group were further sub-grouped as uncontrolled group (HbA1c > 7%) of
diabetic patients and controlled group (HbA1c ≤ 7%) of diabetic patients. MPV was determined by cell counter. Study group and
control group were then compared with regards to MPV and HbA1c. We found significantly higher MPV in diabetics as compared to
non-diabetics. Also, we found a positive co-relation between MPV and HBA1c. One % increase in Hb1Ac led to an increase in 1.45 fl
(1.37-1.52) of MPV. It is hypothesized that platelet hyperactivity in patients with T2DM is related with factors such as hyperglycemia,
hyperlipidemia, insulin resistance, and antioxidant and inflammatory conditions. This study can be of help to physicians, consumers
and policy-makers to decide whether MPV can be incorporated as a tool to assess and monitor the development of microvascular
and macrovascular complications of T2DM.
Keywords: platelet volume, Type 2 Diabetes Mellitus, glycaemic control, HbA1c
Medical Science, 2020, 24(101), 12-21
