Volume 24, Issue 101, January - February, 2020

Assessment of serum lipid profile in patients with thyroid disorders in a rural backdrop of central India

Anubhuti Dixit¹, Mahalaqua Nazli Khatib², Shilpa Gaidhane³, Abhay M Gaidhane⁴, Quazi Syed Zahiruddin⁵

¹Medical Student, Datta Meghe Institute of Medical Sciences (Deemed University)
²Head - Division of Evidence Synthesis; Centre of Excellence School of Epidemiology and Public Health & Professor of Department of Physiology, Datta Meghe Institute of Medical Sciences (Deemed University), Email: nazli.786@rediffmail.com
³Jawaharlal Nehru Medical College; Datta Meghe Institute of Medical Sciences (Deemed University)
⁴Division of Evidence Synthesis; Centre of Excellence School of Epidemiology and Public Health, Datta Meghe Institute of Medical Sciences (Deemed University)
⁵Professor of Department of Community Medicine & Division of Evidence Synthesis; Centre of Excellence School of Epidemiology and Public Health, Datta Meghe Institute of Medical Sciences (Deemed University)

ABSTRACT

Thyroid diseases are among the commonest endocrine disorders worldwide. Thyroid dysfunction can result in lipid abnormalities which increase the risk of endothelial dysfunction, hypertension and cardiovascular disease. This cross-sectional study was conducted to determine changes in serum lipid profiles in patients with thyroid disorders in a rural backdrop of central India and to compare this with normal rural population. Participants were divided into two subgroups: study group with hypothyreosis (n = 49) and control group with euthyreosis (n = 42). Fasting of venous blood sample was collected, and lipid profile was estimated. We found a negative association between thyroid levels and body mass index. Mean serum TG, TC, LDL-C and VLDL-C levels were higher in hypothyroid subjects as compared to euthyroid and hyperthyroid subjects. HDL-C levels were higher in hyperthyroid subjects as compared to hypothyroid subjects but lower than the euthyroid subjects. TC/HDL-C was higher in hypothyroid subjects than hyperthyroid and euthyroid subjects. Thyroid levels were correlated positively with serum HDL-C and negatively correlated with TG, TC, LDL-C, VLDL-C and TG/HDL-C ratio. Findings of this study shows that hypothyrodism is associated with altered lipid disorders. Thus; hypothyroid state has a role in increased cholesterol levels which in turn can be responsible for cardiovascular complications. Therefore biochemical screening for lipid profile is of paramount importance in all patients with thyroid dysfunction and underlying lipid abnormalities should be recognized and treated. Also; thyroid dysfunction should be taken into account when evaluating and treating dyslipidemic patients.

Keywords: Thyroid dysfunction, altered lipid disorders, rural population

Medical Science, 2020, 24(101), 1-11

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