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Volume 21, Issue 85, May - June 2017

About the Cover

Macrophage stimulating protein (MSP)/HGF-linked protein (HGFL) was simultaneously discovered as a protein stimulating macrophage activity and hepatocyte growth factor (HGF) family protein. MSP is produced by epithelial cells, and its receptor, Ron (Recepteur d’origine nantais), is expressed in stromal cells. Ron and Met, an HGF receptor, are also both family receptors. However, HGF is produced by stromal cells, and Met plays some roles on epithelial cells. Therefore, HGF-Met and MSP-Ron signallings show a reciprocal correlations under physiological condition. Although HGF-Met is a well-known signalling promoting cancer, RON overexpression was also observed in some human cancers that originated from epithelial cells, and SP-Ron signalling has important activities in cancer development. MSP induces invasion, metastasis, and drug resistance of cancer cells. Moreover, Ron interacts with Met and the EGF receptor, and they exert various effects in cooperation to achieve malignancy. Ron could be an important target of cancer therapy using monoclonal antibodies and small chemical inhibitors. In this review, we focus on the roles of MSP in cancer development and therapies against MSP-Ron-signal-positive cancers (Ref: Takashi Kato. MSP-Ron signalling in cancer treatment. Medical Science, 2017, 21(85), 114- 118); (Image: s3-eu-west-1.amazonaws.com).

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REVIEW

MSP-Ron signalling in cancer treatment

Takashi Kato

Macrophage stimulating protein (MSP)/HGF-linked protein (HGFL) was simultaneously discovered as a protein stimulating macrophage activity and hepatocyte growth factor (HGF) family protein. MSP is produced by epithelial cells, and its receptor, Ron (Recepteur d’origine nantais), is expressed in stromal cells.

Medical Science, 2017, 21(85), 114-118

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RESEARCH

Reduced expression profile of neurotrophins and their cognitive receptors in the hippocampal region of postmortem suicidal brain

Ritabrata Banerjee, Anup K. Ghosh, Balaram Ghosh, Somnath Bhattacharya, Amal C. Mondal

Suicide is a major public health concern. Although the authors of many studies have examined the neurobiological aspects of suicide, the molecular mechanisms associated with suicidal behavior remain poorly understood, there is increasing evidence that brain-derived neurotrophic factor (BDNF) and Nerve growth factor (NGF) are involved in the pathophysiology and treatment of depression through binding and activating their cognate receptors trk B and trk A respectively.

Medical Science, 2017, 21(85), 119-127

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CASE REPORT

Metastasis of colon cancer to the thyroid: a case report and review of the literature

Zayd.Jastaniah, Pierre Truntzer, Christian Borel, Jean Carvalho

In France, colorectal cancer is the third most common cancer in males and the second most common cancer in females. Thyroid metastasis from CRC is rare. The incidence of metastasis to the thyroid gland in autopsy series varies from 4% to 9%, while in clinical series the prevalence of intra-thyroid metastasis is not more than 1%.

Medical Science, 2017, 21(85), 128-136

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ANALYSIS

Gun violence in north-western India

Naveen K. Simatwal, Shantilal Pargi, Damyanti Ujwal, Prem Chand Meena, Gyan Prakash Gaur, Vinod k. Garg, Gahlot RK

Gun violence is one of the important indicators of level of social and mental health. It is a global problem and causes considerable hazards in a developing country like India, where poverty and violence are not uncommon.

Medical Science, 2017, 21(85), 137-142

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RESEARCH

The situation of Crimean – Congo Hemorrhagic fever in Albania from 2013-2016

Krasniqi Marsida, Bino Silvia

Crimean-Congo hemorrhagic fever is a zoonotic viral disease that can be a serious threat to humans. The transmission of the virus is by ticks bite, by direct contact with blood or tissues from infected animals and by humans to humans by infected persons.

Medical Science, 2017, 21(85), 143-149

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ANALYSIS

An analysis of Prevalence of Supernumerary Teeth in Population of Bhagalpur District of Bihar

Vishal, Sinha DK, Kumar C

The Aim of the study was to determine the prevalence of Supernumerary teeth in population of Bhagalpur district of Bihar. Patients which came for routine Dental checkup and treatment in JLNMC&H during October 2016 to mid-April 2017 were included in the study.

Medical Science, 2017, 21(85), 150-154

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RESEARCH

CRP elevations in patients with schizophrenia

Shashi K. Agarwal

There is a compelling body of evidence relating subclinical chronic inflammation and schizophrenia in adults. Prenatal infections during pregnancy have been shown to be associated with an increased risk of schizophrenia in the offspring during adulthood.

Medical Science, 2017, 21(85), 155-159

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