Volume 18, Issue 42, July - December, 2024

Investigation of the in-vitro and invivo hypoglycemic potential of musa paradisiaca l. (ab) and mangifera indica l. Inflorescences

Silpa IS^♦, Akila E, Krishna Murthy, Neha KB, Kashifa Farheen

Department of Pharmacognosy, Al-Ameen College of Pharmacy, Bangalore, Karnataka, India

^♦Corresponding author
Department of Pharmacognosy, Al-Ameen College of Pharmacy, Bangalore, Karnataka, India

ABSTRACT

Objective: This study aims to investigate the hypoglycemic effects of the inflorescences of Musa paradisiaca L. (AB) and Mangifera indica L., exploring their in-vitro and in-vivo antidiabetic potential. Methods: The study involved alpha-amylase and alphaglucosidase inhibition assays to evaluate in-vitro antidiabetic properties, followed by in-vivo testing using diabetic Wistar rats treated with ethanolic extracts of the plants. Critical parameters measured included blood glucose levels, body weight, and lipid profiles. Histopathological analysis was also conducted to assess tissue recovery. Results: Ethanolic extracts of both plants showed significant inhibition in enzyme assays, indicating potential antidiabetic properties. In diabetic rat models, high doses of the extracts significantly reduced blood glucose levels, improved lipid profiles, and enhanced body weight. Histopathological findings revealed notable recovery in pancreatic and liver tissues. Conclusion: Musa paradisiaca L. (AB) and Mangifera indica L. inflorescences demonstrate considerable antidiabetic effects, with potential for use in diabetes management due to their ability to lower glucose levels, improve lipid metabolism, and support tissue recovery.

Keywords: Musa paradisiaca L., Mangifera indica L., hypoglycemic activity, diabetes mellitus.

Drug Discovery, 2024, 18(42), e20dd2011

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DOI: https://doi.org/10.54905/disssi.v18i42.e20dd2011

Published: 23 November 2024