Volume 18, Issue 42, July - December, 2024

Acute and sub-acute toxicity study of Lonchocarpus laxiflorus leaf methanol extract on albino rats

Abubakar Abdulhamid, Angela Nnenna Ukwuani-Kwaja^♦, Hussain Mustapha Hassan, Abdulhamid Zubairu, Hassan Ibrahim Namaki, Sanusi Ibrahim Mungadi

Department of Biochemistry, Faculty of Life Sciences, Kebbi State University of Science and Technology Aliero, Kebbi State, Nigeria

^♦Corresponding author
Department of Biochemistry, Faculty of Life Sciences, Kebbi State University of Science and Technology Aliero, Kebbi State, Nigeria

ABSTRACT

Toxicology is the vital part of pharmacology which deals with the undesirable effect of phytocompounds on living organisms before they are use as drug or chemical in clinical use. This study is aimed at evaluating the acute and sub-acute toxicity effects of Lonchocarpus laxiflorus leaf methanol extracts (LLMLE). Standard OECD guidelines were used to conduct acute and subchronic toxicity evaluations. The results of acute oral administration of the leaf extracts indicated no mortality up to 14 days after treatment. There was also no sign of toxicity, and the LD50 was assumed to be greater than 3000mg/kg. In sub-chronic toxicity, there was no significant (P>0.05) alteration in animal bodyweight throughout the experimental period suggesting that the extract did not interfere with feeding or regulate appetite. There was also no significant (P>0.05) alteration in all liver biomarkers of all Lonchocarpus laxiflorus leaf methanol extracts treated groups compared to control. Lonchocarpus laxiflorus leaf methanol extracts (LLMLE) did not cause any significant (P>0.05) alteration in kidney function parameters. Similarly, there were no significant (P>0.05) alteration in haematological parameters of all Lonchocarpus laxiflorus leaf methanol extracts treated groups compared to control. Hence, Lonchocarpus laxiflorus leaf methanol extract is not hepatotoxic, nephrotoxic and do not have a haematological effect, thus this research validates the safety of this plant at acute and subchronic administrations

Keywords: Acute, sub-acute, toxicity, Lonchocarpus laxiflorus

Drug Discovery, 2024, 18(42), e18dd1999

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DOI: https://doi.org/10.54905/disssi.v18i42.e18dd1999

Published: 18 August 2024