Volume 17, Issue 39, 2023

About the Cover

The effect of the centrally acting imidazoline agonist rilmenidine was examined in acute visceral and thermal nociceptive pain models, Porsolt’s forced swimming test and rotarod test in mice. Rilmenidine given intraperitoneally (i.p.) at doses of 0.25, 0.5, 1, 2 or 4 mg/kg dose-dependently inhibited the development of abdominal constrictions evoked by i.p. injection of dilute acetic acid, reducing the number of writhes by 38.4–99.8%. The antinociceptive effect of rilmenidine (1 mg/kg, i.p.) was reduced by atropine, the non-selective beta-adrenoceptor blocker propranolol, the α-2 adrenoceptor antagonist yohimbine and the ATP-sensitive potassium channel blocker glibenclamide. The antinociception caused by rilmenidine was enhanced by the α1-adrenoceptor antagonist prazosin and the sympathetic blocker guanithidine. The drug at the dose of 1 or 2 mg/kg produced significant increases in response latencies in the hot plate test. Rilmenidine (0.5-2 mg/kg, i.p.) did not alter the immobility time in the Porsolt’s forced-swimming test or time spent on rotarod testing.

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RESEARCH

The effect of the imidazoline receptor agonist rilmenidine on visceral and thermal nociceptive pain in mice

Omar ME Abdel-Salam, Amany A Sleem

The effect of the centrally acting imidazoline agonist rilmenidine was examined in acute visceral and thermal nociceptive pain models, Porsolt's forced swimming test and rotarod test in mice.

Drug Discovery, 2023, 17(39), e1dd1001

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Liver toxicity produced by the weight reducing agent 2,4 dinitrophenol

Omar ME Abdel-Salam, Fatma A Morsy, Dalia Medhat, Noha N Yassen, Marwa E Shabana

Drug induced liver disease is an important and serious clinical problem. In this study, the effects of administering high doses of the sliming agent 2,4-DNP (2,4- DNP) on the rat liver was examined.

Drug Discovery, 2023, 17(39), e2dd1002

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ANALYSIS

Ethnomedicinal study of the khumi indigenous community in Bandarban district, Bangladesh

Md Salah Uddin, Vashkar Chowdhury, Shaikh Bokhtear Uddin

The current study documents the traditional healers' concept of ethnomedicine among the indigenous Khumi community in Bangladesh's Bandarban Hill District.

Drug Discovery, 2023, 17(39), e3dd1004

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COMMUNICATION

Bioactive compounds in ethanolic extract of Strychnos innocua root using gas chromatography and mass spectrometry (GC-MS)

Alagbe, John Olujimi

Medicinal plants are of great relevance with endless pharmaceutical and therapeutic properties. They are source of wide array of secondary metabolites or bioactive compounds/phytochemicals.

Drug Discovery, 2023, 17(39), e4dd1005

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ANALYSIS

Effect of Andrographis paniculata in experimental models of pain and inflammation

Omar ME Abdel-Salam, Amany A Sleem

We investigated the effect of a standardized extract of the plant Andrographis paniculata in carrageenan induced paw oedema and in acute thermal, electric and visceral inflammatory pain models in rats.

Drug Discovery, 2023, 17(39), e5dd1006

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RESEARCH

Population genetics and diversity of human adenovirus in two tertiary hospitals in Southern Nigeria

Dirisu John, Agbakoba Nneka, Eki-Udoko Fidelis, Elo- Ilo Jacinta C, Oladipo Olukayode, Okwelogu Somadina

The study of dynamic changes in genetic heterogeneity can shed light on the evolution of viruses because it is known that the genetic variety of viral populations within their hosts affects disease.

Drug Discovery, 2023, 17(39), e6dd1007

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Neurocognitive and neuroprotective potential of Mimusops elengi in mice model of scopolamine-induced amnesia

Jayaraman Rajangam, Dharani Prasad Parthasaradhi, Muddukrishnaiah Kotakonda, Narahari N Palei, Alagusundaram Muthumanickam, Navaneetha Krishnan Subramanam, Hima Bindhu

The study was aimed to assess the cognitive and protective potential of methanol extract of Mimusops elengi bark (MEME-B) and flowers (MEME-F) against a mice model of the amnesia paradigm.

Drug Discovery, 2023, 17(39), e7dd1008

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ANALYSIS

Fabrication and characterization of piroxicam loaded Nano emulsions for topical drug delivery to fight osteoarthritic pain

Saman Ali, Shehnila Sabir, Nawal Saif, Nouman Farooq, Haseeb Anwar Dad

Nano systems such as microemulsions (ME) and nano emulsions (NE) offer considerable opportunities for targeted drug delivery to and via the skin. ME and NE are stable colloidal systems composed of oil and water.

Drug Discovery, 2023, 17(39), e8dd1009

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RESEARCH

Effect of propranolol, bisoprolol and terbutaline in acute brain injury induced by malathion in the rat

Omar ME Abdel-Salam, Fatma A Morsy, Amany A Sleem

The pharmacological management of acute malathion poisoning entails besides the use of the specific antidotes atropine and oximes, the administration of other drugs for controlling associated cardiac and respiratory problems.

Drug Discovery, 2023, 17(39), e9dd1010

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ANALYSIS

Characterization of bioactive compounds in Luffa aegptiaca leaf ethanolic extracts using gas chromatography and mass spectrometry

Alagbe JO, Bamigboye Samson, GC Nwosu, DA Agbonika, Kadiri Mercy Cincinsoko

Medicinal plants contain several bioactive compounds or phytochemicals that therapeutically exert wide spectrum of biological activities such as; antimicrobial, antifungal, antiviral, anti-inflammatory, hepato-protective.

Drug Discovery, 2023, 17(39), e10dd1011

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Phytochemical and antibacterial activity of Mormodica balsamina leaves crude extract and fractions

Abubakar Abdulhamid, Sanusi Ahmad Jega, Ibrahim Sani, Ahmad Ibrahim Bagudo, Rabiat Abubakar

Momordica balsamina (Balsam apple) leaves is used in the management of several human diseases, it also serves as vegetable to many tribes in African countries, Nigeria inclusive.

Drug Discovery, 2023, 17(39), e11dd1012

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Formulation of sustained release diclofenac sodium tablets using a blend of hydrophobic and hydrophilic polymers

Sylvester O Eraga, Lawretta N Ijeh, Nnabuike D Nnamani, Florence E Eichie

The limitations of conventional oral dosage forms, particularly those containing drugs with short biological half-lives has led to the development of sustained release formulations.

Drug Discovery, 2023, 17(39), e12dd1013

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Network pharmacology-based assessment of anti-inflammatory action of phytocompounds derived from Nigella sativa and Moringa oleifera

Funmilayo ID Afolayan, Christopher T Tarkaa

Studies have shown that Nigella sativa and Moringa oleifera possess anti-inflammatory activity, however, the molecular targets involved in their mechanisms of action are not known.

Drug Discovery, 2023, 17(39), e13dd1016

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Protection by gabapentin against indomethacin and ethanol-induced gastric mucosal damage in the rat. A histological and histochemical study

Omar ME Abdel-Salam, Nermeen Shaffie

Gabapentin is an antiepileptic drug which is widely used to treat chronic neuropathic pain. In this study, the effect of gabapentin on gastric mucosal damage induced in the rat by indomethacin or 96% ethanol was examined.

Drug Discovery, 2023, 17(39), e14dd1014

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COMMUNICATION

Therapeutic drug monitoring: Fundamentals and optimization

Ahmed S Ali, Mahran S Abdel-Rahman, Mohammed A Bazuhair

Background: Therapeutic drug monitoring (TDM) is a clinical pharmacokinetic service aimed to optimize the pharmacotherapy of certain drugs such as those with a narrow therapeutic range and complicated pharmacokinetics.

Drug Discovery, 2023, 17(39), e15dd1015

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REPORT

Formulation and evaluation of curcumin loaded ethosomes as novel drug delivery system

Jyoti Singh Rajput, Abbaraju Krishna Sailaja

Curcumin having an excellent safety profile including anti-inflammatory, antioxidant, anti-cancer and antimicrobial activity. Curcumin will help in the management of oxidative and inflammatory conditions.

Drug Discovery, 2023, 17(39), e16dd1917

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ANALYSIS

Phytochemical constituent, acute toxicity and analgesic activities of Dichrostachys cinerea leaves methanol extract

Abubakar Abdulhamid, Aminu Umar Argungu, Habib Musa Abubakar, Abdulhamid Zubairu

There are several pain relievers available on the market, but current medications are associated with certain side effects, such as gastrointestinal irritation, bronchospasm, fluid retention and prolonged bleeding time.

Drug Discovery, 2023, 17(39), e17dd1914

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Development and characterization of felodipine fast dissolving tablets

Raghavendra Kumar Gunda, Suresh Kumar JN, Mansur Ali SK, Naveena B, Yamini B, Priyanka CH, Sravani L

Objective: The current study's objective is to develop and characterise fast-dissolving tablets (FDT) for felodipine. Felodipine an excellent calcium channel blocker. It is primarily used to effectively control angina pectoris and hypertension.

Drug Discovery, 2023, 17(39), e18dd1916

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REPORT

A curcumin loaded niosomes as novel drug delivery system by ether injection method

Chelsea Ruth John, Abbaraju Krishna Sailaja

Curcumin is a natural chemical which is produced by a plant called Curcuma longa species. Curcumin has been shown to be an antioxidant, anti-inflammatory, anti-viral, anti-bacterial, anti-fungal and anti-cancer activity.

Drug Discovery, 2023, 17(39), e19dd1918

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RESEARCH

In silico screening and molecular docking of spiroindimicin A-H targeting Insulin Growth Factor 1 Receptor (IGF-1R) for cancer treatment

Thet Htwe Aung, Chandan Shivamallu, Shiva Prasad Kollur

Spirocyclic compounds have the potential to become anticancer drugs, hence it is anticipated that spiroindimicin A-H, which has moderate cytotoxicity against numerous cancer cell lines.

Drug Discovery, 2023, 17(39), e20dd1923

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Biological evaluation of Ficus elastica leaves for antidepressant and anxiolytic activity

Akash Koley, Shyamal Kumar Biswas, Nabanita Sadhukhan, Souvik Ghosh, Pujan Sasmal

Background: Medicinal plants play a vital role in questing of drug discovery as numerous of conjugates are present. Ficus plants, which are members of the Moraceae family, are frequently employed in traditional medicine.

Drug Discovery, 2023, 17(39), e21dd1924

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REVIEW

Analytical quality by design used in the pharmaceutical industry: A review

Khagga Bhavya Sri, Saba Fatima, Mogili Sumakanth

During the previous decade, the pharmaceutical industry has grown quickly as a result of its focus on product safety, quality and efficacy. By utilizing numerous scientific methods like QbD (Quality by Design) and PAT (Process Analytical Technology).

Drug Discovery, 2023, 17(39), e22dd1930

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PERSPECTIVE

Contribution of a pharmaceutical professional during the pandemic COVID-19

Ajay Kumar Garg, Saurabh Kumar Sinha, Chennu MM Prasada Rao, Rajeshwari T, Ranjan Kumar Singh, Khushboo Shrimali

When the (SARS-CoV-2) initially surfaced in Wuhan (China) in December 2019, the Coronavirus Disease 2019 (COVID-19), an ailment it caused, spread quickly throughout the world.

Drug Discovery, 2023, 17(39), e23dd1932

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ANALYSIS

Anthelmintic effects of two extracts of traditional medicinal plants (Balanites aegyptica and Khaya senegalensis) on gastrointestinal parasites in goats

Alain Loabe Pahimi, Christophe Wang-Baa Temoa, Pierre Wandjoumbe, Christine Soukbo, Ali Salihou, Souley Bagari Iya, Yannick Pierre Mole Zogo

This study was conducted with the aim of enhancing plants for treatment of gastrointestinal parasites in goats, as an alternative to the chemical control already known.

Drug Discovery, 2023, 17(39), e24dd1934

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Analysis of multi-target directed novel non-peptidic chalcone scaffold as potential malaria plasmodium proteases inhibitors

Sodeeq A Babalola, Muhammad Y Hayatuddeen, Idris A Yunusa, Hamza N Asmau

Malaria remain an epidermic infectious disease that is ravaging the world most especially sub-Sahara Africa. Due to the prevalent of Plasmodium parasites that are resistant to first-line antimalarial drugs.

Drug Discovery, 2023, 17(39), e25dd1935

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Computational simulations of phytoconstituents derived from Phyllanthus amarus against Plasmodium falciparum molecular targets

Afolayan FID, Ibrahim S

There has been an increase in the resistance of plasmodium parasites to already available malaria prevention drugs. Hence, the need for novel malaria-preventive medications.

Drug Discovery, 2023, 17(39), e26dd1937

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