Volume 17, Issue 39, January - June, 2023

Effect of Andrographis paniculata in experimental models of pain and inflammation

Omar ME Abdel-Salam^1♦, Amany A Sleem²

¹Department of Toxicology and Narcotics, Medical Research and Clinical Studies Institute, National Research Centre, Cairo, Egypt
²Department of Pharmacology, Medical Research and Clinical Studies Institute, National Research Centre, Cairo, Egypt

^♦Corresponding author
Department of Toxicology and Narcotics, Medical Research and Clinical Studies Institute, National Research Centre, Dokki, Cairo, Egypt

ABSTRACT

We investigated the effect of a standardized extract of the plant Andrographis paniculata in carrageenan induced paw oedema and in acute thermal, electric and visceral inflammatory pain models in rats. The effects of the extract on spontaneous motor activity, haloperidol-induced locomotor impairment and blood glucose level were also examined. Results indicated that A. paniculata given at doses of 27, 54 or 108 mg/kg, via the intra peritoneal (i.p.) route caused significant inhibition of the inflammatory paw oedema caused by sub planter injection of carrageenan in a dose dependant manner. In tests of nociception, A. paniculata displayed antinociceptive activity in the hot plate, tail electric and acetic acid-induced visceral pain tests. The latency on the hot plate test was delayed by 67.7% and 72.9% while the threshold current required to elicit vocalization in tail electric stimulation test increased by 25% and 30.3% after treatment with A. paniculata at 54 and 108 mg/kg, respectively. The above doses of A. paniculata caused significant inhibition of the acetic acid-induced writhing by 29.8% and 43.7%, respectively. A. paniculata showed no significant effect on spontaneous motor activity or the locomotor impairment caused by haloperidol. It also had no significant effect on blood glucose level in normal rats. Collectively, these results indicated an analgesic an anti-inflammatory activity for A. paniculata at doses devoid of a sedative effect.

Keywords: Andrographis paniculata, thermal pain, visceral pain, carrageenan, inflammation

Drug Discovery, 2023, 17(39), e5dd1006

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DOI: https://doi.org/10.54905/disssi.v17i39.e5dd1006

Published: 27 January 2023