Volume 17, Issue 39, January - June, 2023

Formulation and evaluation of curcumin loaded ethosomes as novel drug delivery system

Jyoti Singh Rajput¹, Abbaraju Krishna Sailaja¹

¹Department of Pharmaceutics, RBVRR Women’s college of Pharmacy, Affiliated to Osmania University, Hyderabad, India

ABSTRACT

Curcumin having an excellent safety profile including anti-inflammatory, antioxidant, anti-cancer and antimicrobial activity. Curcumin will help in the management of oxidative and inflammatory conditions, metabolic syndrome, arthritis, anxiety and hyperlipidemia etc. With all these advantages it will also show some poor oral bioavailability and limit the usage of oral dosage form. Curcumin loaded Ethosomes are prepared to overcome the problem of bioavailability and permeation. It can be prepared by two methods hot method and cold method. The Curcumin loaded ethosomes are successfully prepared and the maximum amount of drug release was found to be 72% in cold method while 42% in hot method in which cold method giving more amount of drug release as compared with hot method. Ethosomes are the vesicular drug delivery system which consists of various advantages to the conventional Dosage form. These are the non-invasive dosage form which will enable the drug to reach the deeper layer to the skin with the lesser side effects which will cause increase with their application. These are soft, vesicular delivery which enhances the action of active drug. The size ranges about 10 nanometers to micrometre. These are convenient for the usage with lesser harm. Ethosomes are the modified form of liposome that consists of high content of ethanol.

Keywords: Curcumin, Ethanol, Propylene glycol, Buffer

Drug Discovery, 2023, 17(39), e16dd1917

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DOI: https://doi.org/10.54905/disssi.v17i39.e16dd1917

Published: 05 April 2023