Volume 16, Issue 38, 2022

About the Cover

Averrhoa carambola is one of the ornamental plants that are becoming increasingly popular because of its medicinal properties. This study assesses the bioactive components of Averrhoa carambola ethanol leaf and fruit extracts using Gas Chromatography-Mass Spectrometer. Acute toxicity study was also carried out on wistar strain albino mice using standard procedures. The varying doses of the extracts were administered orally to the male wistar albino mice and signs accompanying toxicity and possible death of animals were monitored. Eight bioactive phyto components were identified in the GCMS analysis of Averrhoacarambola ethanol leaf extract, with Bis (2-ethylhexyl) phthalate having the highest percentage concentrations (24.31%) quantitatively. The ethanol fruit extract had six bioactive components identified, with citral having the highest concentration of 20.59%. Acute toxicity studies revealed the ethanol leaf extract had a median lethal dose (LD50) value of 3605.55mg/kg body weight. Conversely, the ethanol fruit extract of A. carambola showed no lethal signs of morbidity and mortality even at doses up to 5000mg/kg body weight.

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RESEARCH

Effect of the antidepressant drug dapoxetine on acute liver injury caused by carbon tetrachloride in the rat

Omar ME Abdel-Salam, Eman R Youness, Fatma A Morsy, Amany A Sleem

We examined the effect of dapoxetine, a selective serotonin-reuptake inhibitor used in treatment of premature ejaculation in the carbon tetrachloride (CCl4) model of acute liver injury

Drug Discovery, 2022, 16(38), 76-85

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GC-MS analysis of bioactive composition of Averrhoa carambola leaf and fruit extracts and acute toxicity study in Albino Mice

Uju OP, Ukairo ID, Emejulu AA

Averrhoa carambola is one of the ornamental plants that are becoming increasingly popular because of its medicinal properties

Drug Discovery, 2022, 16(38), 86-93

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The effect of high doses of the slimming agent 2,4 dinitrophenol in the rat brain: A biochemical and histopathological study

Abdel-Salam OME, Medhat D, Morsy FA, Shabana ME, Yassen NN, Sleem AA

The uncoupler of mitochondrial oxidative phosphorylation 2,4 dinitrophenol (2,4-DNP) is used as a weight reducing agent and there are reports of toxicity and deaths due to the agent

Drug Discovery, 2022, 16(38), 94-103

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ANALYSIS

Phytochemical constituent, acute toxicity and hypoglycemic potential of dichrostachys cinerea methanol leaf extract.

Abdulhamid Abubakar, Habiba Aminu, Aminu Isah, Abdulhamid Zubairu

Diabetes mellitus (DM) is a major public health problem worldwide, herbal derivatives have proved to be more efficient in the treatment of diabetes

Drug Discovery, 2022, 16(38), 104-109

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RESEARCH

Effect of the 5-alpha-reductase inhibitor finasteride on experimentally-induced pain, inflammation, gastric lesions and liver injury

Abdel-Salam OME, Sleem AA, Omara EA

Finasteride, a 5-alpha-reductase inhibitor, used in treatment of benign prostatic hypertrophy was evaluated in acute nociceptive pain models

Drug Discovery, 2022, 16(38), 110-123

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ANALYSIS

Hepatoprotective effects of gabapentin alone or with silymarin in carbon tetrachloride-induced hepatic damage in rats

Omar M E Abdel-Salam, Nermeen Shafee, Amany A Sleem

The aim of this study was to examine the effect of gabapentinoid drug gabapentin alone or in combination with the antioxidant silymarin on the carbon tetrachloride (CCl4)-induced liver injury in rats.

Drug Discovery, 2022, 16(38), 124-130

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