Volume 16, Issue 37, January - June, 2022

Solvent-free synthesis of polymethoxy and dichloro p-nitrophenyl hydrazones

Babalola SA^1♦, Idris AY¹, Sani YM¹, Hamza A¹, Igie N², Muhammad H¹, Erumiseli OG¹, Bakare LO¹

¹Department of Pharmaceutical and Medicinal Chemistry, Ahmadu Bello University, Zaria, Nigeria.
²Department of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, USA.

^♦Corresponding author
Babalola Sodeeq Adewale, Department of Pharmaceutical and Medicinal Chemistry Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Kaduna State, Nigeria

ABSTRACT

A solvent-free method for the synthesis of novel p-nitrophenyl hydrazones was successfully developed. The condensation of the p-nitrophenyl hydrazine with aromatic aldehydes through this mechanochemical technique furnished three products 3a-c with moderate to high yield. The developed method is eco-friendly, efficient, simple, and convenient, and indicated high reproducibility, short reaction time, catalyst-free, simple workup, and afforded pure and unsolvated products.

Keywords: Green synthesis, p-nitrophenyl hydrazine, solvent-free, mechanochemistry, p-nitrophenyl hydrazine

Drug Discovery, 2022, 16(37), 63-67

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