Volume 16, Issue 37, January - June, 2022

Antibacterial and antifungal activities of tobramycin, gentamycin, neomycin and amikacin derivatives, derived from vanillin

Munan A^1,2♦, Khan AJ¹, Khan M¹, Abbas G¹, Ahmad E¹, Hussain A¹, Khan S¹, Khan AK¹, Yousaf AH¹

¹Ophth Pharma (Pvt) Ltd Korangi industrial Area Karachi, Pakistan
²Department of Chemistry University of Karachi, Pakistan

^♦Corresponding author
Ophth Pharma (Pvt) Ltd Korangi industrial Area Karachi, Pakistan; Department of Chemistry University of Karachi, Pakistan

ABSTRACT

Vanillin was used to synthesis a number of derivatives of Tobramycin, Gentamycin, Neomycin, and Amikacin. The creation of the imine bond and its reduction with NaBH4 were accomplished. The imine bond was confirmed by stretching band 1650cm-1 between 1625cm-1 and 1660cm-1 by FTIR, which displayed absorption at 400nm wave length in UV-Visible Spectroscopy. Antibacterial and antifungal activities were tested on S. Aureus, Bacillus Sb, E.Coli, and Salmonella Sp, and it was shown to be two times that of parent medicines while mild antifungal activities were found.

Keywords: Aminoglycosides, Derivatives, Vanillin, Synthesis, Antibacterial and antifungal

Drug Discovery, 2022, 16(37), 29-35

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