Volume 14, Issue 34, July - December, 2020

Analysis of adverse reactions associated with use of psychiatric medications in a teaching hospital - A retrospective study

Lakshmi Prasanna T^1♦, Stalin C¹, Ramachandra Bhat C²

¹Patient safety- Pharmacovigilance Associate, Pharmacovigilance Programme of India (PVPI), National Coordination Centre, Indian Pharmacopoeia Commission, Ghaziabad- India.
²Professor and Head, Department of Pharmacology, Govt. Kilpauk Medical college- Chennai, Tamilnadu, India.

^♦Corresponding author
T. LAKSHMI PRASANNA, Patient safety- Pharmacovigilance Associate, National Coordination Centre, Indian Pharmacopoeia Commission, Ghaziabad- India, Phone-8682951688, E-Mail- yesuprasanna@gmail.com.

ABSTRACT

Drug therapy for psychiatric disorders is frequently associated with various adverse drug reactions (ADRs). Our study was based on analyzing the reports received by spontaneous ADR reporting program. Collected data were evaluated to understand the pattern with respect to patient demographics, nature of the reactions, characteristics of the drugs involved and outcome of the adverse drug reactions. Causality, severity, and preventability of reactions were analyzed. Most of the ADRs were reported in the age group of 31-45 (36 %) and female preopondarance (53.6 %) was observed. Most of the reported ADRs were of Type A68.8%. Phenytoin (23.2%) was found to be the most common drug which caused ADRs. Skin and appendages disorders (56.8%) were the most affected system. Our current study supports the need of pharmacovigilance in psychiatry practice to promote early detection of ADRs and passing on information on drug safety to psychiatrists regarding the probability of ADRs to promote patient safety

Keywords: Adverse drug reactions, Psychiatric Medications and Pharmacovigilance

Drug Discovery, 2020, 14(34), 231-237

PDF