Volume 14, Issue 34, July - December, 2020

Functionality assessment of microcrystalline cellulose derived from rice husk as a pharmaceutical excipient

Frank O Ohwoavworhua^1,2, Augustine O Okhamafe²

¹Department of Pharmaceutical Sciences, College of Pharmacy, Howard University, Washington DC 20059, USA
²Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Benin, Benin City 300001, Nigeria

ABSTRACT

Herein, microcrystalline cellulose obtained from rice husk (RH-MCC) has been evaluated for its role as a diluent in ascorbic acid tablet formulation, as well as disintegrant in dicalcium phosphate (DCP) compacts. Critical material attributes of the MCC including morphology (SEM), thermal behavior (DSC), micromeritic, flow, swelling and sorption properties correlated well to its roles, and are comparable to the well-known commercial brand, Avicel PH 101. Consequently, RH-MCC could function as a potential pharmaceutical excipient.

Keywords: Microcrystalline cellulose, Functionality assessment, Tablet, Rice husk

Drug Discovery, 2020, 14(34), 337-345

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