Volume 14, Issue 34, July - December, 2020

Anti-tubercular Potential of Ethylenediamine Derivatives: A Short Review

Mohammad Asif

Department of Pharmacy, GRD (PG) IMT, Dehradun, (Uttarakhand), 248009, India

^♦Corresponding author
Frank O. Ohwoavworhua Department of Pharmaceutical Sciences, College of Pharmacy, Howard University, Washington DC, USA Department of Chemical and Biomolecular Engineering, College of Engineering and Architecture, Howard University, Washington DC, USA; Email: frankohwo@yahoo.com

ABSTRACT

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. Control of TB is complicated by the long-course therapy regimens, the incapability to eliminate latent organisms, and the increasing appearance of multidrug resistant strains of M. tuberculosis. New drugs for the prevention of TB are urgently required, including developments of new drug regimens to minimize the emergence of drug resistance, to treat MDR-TB patients and to eliminate the latent bacteria. Recent years, many new structural classes of anti-TB agents are come out, some of which exhibit promising activities against vulnerable and resistant strains of M. tuberculosis. In particular, the newly discovered ethylenediamine derivatives with significant anti-TB activity and generated considerable excitement

Keywords: Ethylenediamines, Mycobacterium tuberculosis, drug resistance, drug development

Drug Discovery, 2020, 14(34), 307-313

PDF