Volume 14, Issue 34, July - December, 2020

Formulation and evaluation of microspheres loaded with methotrexate drug

Venkata Swamy M^1♦, Ramana Murthy KV²

¹Department of Pharmaceutical Biotechnology, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur- 522510, Andhra Pradesh, India
²Department of Pharmaceutical Technology, A. U. College of Pharmaceutical Sciences, Andhra University, Visakhapatnam - 530003, Andhra Pradesh, India

^♦Corresponding author
Department of Pharmaceutical Biotechnology, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur- 522510, Andhra Pradesh, India; E-mail: mvenkataswamy93@gmail.com

ABSTRACT

The main aim of the research work was the formulation and evaluation of controlled release microspheres loaded with methotrexate drug. Literature review showed that suspensions of degradable microspheres can be employed for sustained drug release at desirable doses. They used as carriers for anticancer drugs. These spheres manufactured in micron size. For this preparation used ethyl cellulose and other excipients. Hence it was investigated and microspheres were prepared with anticancer drug like methotrexate. These are tested furthermore with scanning electron microscopy studies, Fourier transform infra red spectroscopy studies and dissolution studies.

Keywords: formulation, microspheres, methotrexate, controlled release

Drug Discovery, 2020, 14(34), 290-295

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