Volume 26, Issue 128, October 2022

Peripheral nerve excitability among males in type-2 diabetes mellitus with and without diabetic neuropathy: A cross-sectional study

Riyas Basheer KB^1♦, Dinesh KVN², Subhashchandra Rai³, Mohammed Arshak AT⁴

¹Associate Professor, Physiotherapy, Tejasvini Physiotherapy College, Kudupu, Mangalore, Karnataka, India
²HOD & Professor, Orthopedics, Srinivas Institute of Medical Sciences, Mukka, Surathkal, Mangalore, Karnataka, India
³Professor & Principal, Physiotherapy, Tejasvini Physiotherapy College, Kudupu, Mangalore, Karnataka, India
⁴Consultant Physiotherapist, Kenz Rehab Physiotherapy Centre, Koppam, Palakkad, Kerala, India

^♦Corresponding author
Associate Professor, Physiotherapy, Tejasvini Physiotherapy College, Kudupu, Mangalore, Karnataka, India

ABSTRACT

Background and Aim: Diabetic neuropathy increases with the duration of diabetes and also poor glycemic control fasten the disability associated with neuropathy. This leads to a change in the nerve excitation and action potential propagation. Rheobase and Chronaxie values from SD curve give the excitability of the nerve. This study aims to find the peripheral nerve excitability by using Rheobase and Chronaxie values based on the neuropathy status of T2DM subjects. Materials and Methods: This was a cross-sectional study conducted on 213 subjects including 141 T2DM subjects and 72 non-diabetic subjects. T2DM subjects were classified into two groups based on the duration of diabetes (< 10 years & >10 years). All subjects nerve excitability from proximal and distal muscle groups by using Rheobase and Chronaxie value obtained from SD curve. Results: This study shows that 33.8% of T2DM with < 10 years and 68.60% of T2DM with > 10 years having neuropathy. In all the groups both Rheobase and Chronaxie, values show statistically significant differences (p<0.001) in all the muscle groups. The Rheobase and Chronaxie values were higher in T2DM with > 10 years followed by T2DM with < 10 year and Non diabetic group. Conclusion: Our study states that Rheobase and Chronaxie values are higher in T2DM with > 10 years and also failed to prove a statistically significant difference between neuropathic and non-neuropathic TDM in nerve excitabilities based on the duration of diabetes.

Keywords: Type-2 Diabetes Mellitus, Nerve Excitability, Rheobase, Chronaxie, SD Curve, Neuropathy, Peripheral Nerves

Medical Science, 2022, 26, ms396e2427

PDF

DOI: https://doi.org/10.54905/disssi/v26i128/ms396e2427

Published: 05 October 2022