Medical Science
Volume 26, Issue 124, June 2022
Effect of buspirone hydrochloride on kidneys of the pregnant and their fetuses an experimental study
Ali Hassan A Ali1,2♦, Turky NI Alhuwail3, Salman S Bin Ofisan3, Abdullah Taher Uahua Marer3, Ibrahim Mohammed Alobaidi3, Mohammad Saleh Alhamdan3, Bader Manaja Alotaibi3, Nasser Salman AL Saloom3, Abdulrahman Abdullah Aldaghfag3, Faisal Abdulaziz O Alghamdi3
1Anatomy Department, College of Medicine, Prince Sattam Bin
Abdulaziz University, Al-Kharj 11942, KSA
2Anatomy Department, Faculty of Medicine, Al-Azhar University, Cairo,
Egypt
3College of Medicine, Prince Sattam Bin Abdulaziz University, Al-Kharj,
KSA
♦Corresponding author
Anatomy Department, College of Medicine, Prince Sattam Bin Abdulaziz
University, Al-Kharj 11942, KSA;
Anatomy Department, Faculty of Medicine, Al-Azhar University, Cairo,
Egypt
ABSTRACT
A member of the anxiolytics pharmacological class, buspirone is an anti-anxiety medication. Buspirone is a sedative medication that is frequently used to relieve tension. The goal of this study was to see how buspirone hydrochloride affected the kidneys of pregnant rats and their offspring. Thirty-three pregnant female rats were divided into three groups. Pregnant rats in the first group received distilled water orally as a control. The second category of pregnant rats received an oral dose of buspirone hydrochloride at a daily dose of 0.27 mg/100 g for fifteen days. From the sixth to the twentieth day of pregnancy, pregnant rats of last group were given buspirone hydrochloride at a dose of 0.41 mg/100 gm for fifteen days. For the histological and histochemical examinations, kidney tissues were collected from pregnant rats and selected from their fetuses of all groups killed on the 20th day of gestation. Both treated groups' maternal and foetal kidney tissues showed various alterations after treatment with buspirone, which were particularly noticeable at the high concentration dose. The current investigation discovered that using the drug Buspirone caused many histological and histochemical changes in the kidney tissues.
Keywords: Buspirone Hydrochloride, Pregnant, Fetuses, Kidney
Medical Science, 2022, 26, ms252e2354
DOI: https://doi.org/10.54905/disssi/v26i124/ms252e2354
Published: 27 June 2022
