Volume 26, Issue 124, June 2022

Green tea's antioxidant properties protect the pancreas in diabetics: An experimental study

Ali Hassan A Ali^1,2♦, Faleh Mubarak Aldawsari³, Murdhi Yousef M Alanazi⁴, Faisal Hassan Sumaili⁴, Abdullah Mulfi M Alanazi⁴, Ali Awadh Ali Alahmari⁴, Saleh Basheer S Alanazi⁴, Musab Sultan A Alrezehi⁴, Ali Hassan M Alnakhli⁴

¹Anatomy Department, College of Medicine, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, KSA
²Anatomy Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
³Internal Medicine Department, King Khalid Hospital, Ministry of Health, Al-Kharj, KSA
⁴College of Medicine, Prince Sattam Bin Abdulaziz University, Al-Kharj, KSA

^♦Corresponding author
Anatomy Department, College of Medicine, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, KSA Anatomy Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

ABSTRACT

Diabetes mellitus is one of the most common and widespread metabolic illnesses worldwide. Hyperglycemia is a symptom of this condition, which is caused by problems with insulin secretion, insulin action, or both. Various medicinal plant species are used as a traditional treatment for diabetes mellitus, such as green tea, which is one of these plants whose extract has been used to treat diabetic patients for many years. The goal of this study was to see if green tea had any antioxidant benefits on the pancreas of alloxan-induced diabetic male albino rats. This experiment involved albino rats weighing between 110 and 120 grams. Three groups of animals were created. Control untreated normal healthy group, Alloxan-induced diabetic group and diabetic group treated with green tea. Tissue samples from diabetic and treated rats were collected and pathologically evaluated to determine the degradation of pancreatic cells in diabetic rats. In diabetic rats, biochemical data revealed a significant decrease in serum insulin, body weight, and total proteins when compared to the control group. Most of these measures improved significantly when diabetes rates were managed daily with green tea. In comparison to the control group, there was a significant improvement in morphological changes in diabetic groups after treatment with green tea in pancreatic tissues. Green tea, it may be concluded, can be used as an antidiabetic drug to lower blood glucose levels and protect against the harmful consequences of diabetes.

Keywords: Diabetes mellitus, Pancreas, Green tea, Alloxan, Oxidative stress

Medical Science, 2022, 26, ms202e2315

PDF

DOI: https://doi.org/10.54905/disssi/v26i124/ms202e2315

Published: 03 June 2022