Volume 24, Issue 106, November - December, 2020

Unraveling the Role of CD4 and CD8 in Patients with Type-2 Diabetes Mellitus

Mohamed Mohey^1♦, Hanan Soliman², Ahmed Okasha³

¹PhD candidate at Department of Biochemistry, Faculty of Science, Beni-Suef University, Beni-Suef 62511, Egypt
²Professor of Biochemistry at Department of Biochemistry , Faculty of Science, Beni-Suef University, Beni-Suef 62511, Egypt
³Assistant professor of Biochemistry at Department of Biochemistry, Faculty of Medicine, Minia University, Minia 61519, Egypt

^♦Corresponding author
PhD candidate at Department of Biochemistry, Faculty of Science, Beni-Suef University, Beni-Suef 62511, Egypt

ABSTRACT

Diabetes mellitus is a serious metabolic disorder that causes considerable disease and mortality with micro- and macro-vascular complications. Long-lasting diabetes is poorly controlled and often leads to nephropathy and cardiovascular complications. To a greater extent studies indicate that T2DM is a protracted inflammatory disease associated with the immune system. The present study was therefore hypothesized to investigate and further investigate immune changes by evaluating CD4 and CD8 markers. Subjects were divided into two groups: healthy people (control group) and diabetic patients of type 2 (diabetic group). In comparison with the control group, our study shows a significant increase in the diabetic group in CD4 and CD8. Our study shows a significant increase in HbA1c in diabetic groups compared to the control group, shows significant rising in lipid profile (total cholesterol, LDL, and Triglycerides) in diabetic groups compared to the control group except for HDL which decreased in diabetic group compared to control group.

Keywords: DM, CD4, CD8, flow-cytometry

Medical Science, 2020, 24(106), 4311-4320

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